node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4921524J17Rik | Mier3 | ENSMUSP00000040975 | ENSMUSP00000104895 | UPF0547 protein C16orf87 homolog; Belongs to the UPF0547 family. | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.503 |
Arl4a | Mier3 | ENSMUSP00000114458 | ENSMUSP00000104895 | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.472 |
Bahd1 | Mier3 | ENSMUSP00000043130 | ENSMUSP00000104895 | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.502 |
Ctbs | Mier3 | ENSMUSP00000059167 | ENSMUSP00000104895 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.525 |
Ctbs | Pde12 | ENSMUSP00000059167 | ENSMUSP00000059666 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | 0.528 |
Higd1a | Mier3 | ENSMUSP00000054881 | ENSMUSP00000104895 | HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.476 |
Higd2a | Mier3 | ENSMUSP00000026986 | ENSMUSP00000104895 | HIG1 domain family member 2A; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.552 |
Mier3 | 4921524J17Rik | ENSMUSP00000104895 | ENSMUSP00000040975 | Mesoderm induction early response protein 3; Transcriptional repressor. | UPF0547 protein C16orf87 homolog; Belongs to the UPF0547 family. | 0.503 |
Mier3 | Arl4a | ENSMUSP00000104895 | ENSMUSP00000114458 | Mesoderm induction early response protein 3; Transcriptional repressor. | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity). | 0.472 |
Mier3 | Bahd1 | ENSMUSP00000104895 | ENSMUSP00000043130 | Mesoderm induction early response protein 3; Transcriptional repressor. | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). | 0.502 |
Mier3 | Ctbs | ENSMUSP00000104895 | ENSMUSP00000059167 | Mesoderm induction early response protein 3; Transcriptional repressor. | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). | 0.525 |
Mier3 | Higd1a | ENSMUSP00000104895 | ENSMUSP00000054881 | Mesoderm induction early response protein 3; Transcriptional repressor. | HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity). | 0.476 |
Mier3 | Higd2a | ENSMUSP00000104895 | ENSMUSP00000026986 | Mesoderm induction early response protein 3; Transcriptional repressor. | HIG1 domain family member 2A; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity). | 0.552 |
Mier3 | Mocs2 | ENSMUSP00000104895 | ENSMUSP00000125797 | Mesoderm induction early response protein 3; Transcriptional repressor. | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. | 0.524 |
Mier3 | Mrps30 | ENSMUSP00000104895 | ENSMUSP00000022245 | Mesoderm induction early response protein 3; Transcriptional repressor. | 28S ribosomal protein S30, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL65 family. | 0.474 |
Mier3 | Pde12 | ENSMUSP00000104895 | ENSMUSP00000059666 | Mesoderm induction early response protein 3; Transcriptional repressor. | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | 0.460 |
Mier3 | Prmt2 | ENSMUSP00000104895 | ENSMUSP00000097167 | Mesoderm induction early response protein 3; Transcriptional repressor. | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. May inhibit NF-kappa-B transcription, and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). Has a negative regulation effect on G1 to S transition of mitotic cell cycle. Involved in growth regulation. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. E [...] | 0.523 |
Mocs2 | Mier3 | ENSMUSP00000125797 | ENSMUSP00000104895 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.524 |
Mrps30 | Mier3 | ENSMUSP00000022245 | ENSMUSP00000104895 | 28S ribosomal protein S30, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL65 family. | Mesoderm induction early response protein 3; Transcriptional repressor. | 0.474 |
Pde12 | Ctbs | ENSMUSP00000059666 | ENSMUSP00000059167 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). | 0.528 |