node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cnpy1 | Cnpy4 | ENSMUSP00000113944 | ENSMUSP00000106559 | Protein canopy homolog 1. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | 0.587 |
Cnpy2 | Cnpy4 | ENSMUSP00000151918 | ENSMUSP00000106559 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | 0.779 |
Cnpy2 | Hsp90b1 | ENSMUSP00000151918 | ENSMUSP00000020238 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family. | 0.417 |
Cnpy4 | Cnpy1 | ENSMUSP00000106559 | ENSMUSP00000113944 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Protein canopy homolog 1. | 0.587 |
Cnpy4 | Cnpy2 | ENSMUSP00000106559 | ENSMUSP00000151918 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | 0.779 |
Cnpy4 | Ergic3 | ENSMUSP00000106559 | ENSMUSP00000006035 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi. | 0.458 |
Cnpy4 | Gml | ENSMUSP00000106559 | ENSMUSP00000094131 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Glycosylphosphatidylinositol-anchored molecule-like. | 0.550 |
Cnpy4 | Hsp90b1 | ENSMUSP00000106559 | ENSMUSP00000020238 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family. | 0.538 |
Cnpy4 | Lrig3 | ENSMUSP00000106559 | ENSMUSP00000074360 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Leucine-rich repeats and immunoglobulin-like domains protein 3; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. | 0.501 |
Cnpy4 | Lrrc40 | ENSMUSP00000106559 | ENSMUSP00000071956 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Leucine-rich repeat-containing protein 40. | 0.607 |
Cnpy4 | Ly96 | ENSMUSP00000106559 | ENSMUSP00000026881 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. | 0.521 |
Cnpy4 | Tlr4 | ENSMUSP00000106559 | ENSMUSP00000045770 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding t [...] | 0.663 |
Cnpy4 | Unc93b1 | ENSMUSP00000106559 | ENSMUSP00000124272 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | Protein unc-93 homolog B1; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. | 0.482 |
Ergic3 | Cnpy4 | ENSMUSP00000006035 | ENSMUSP00000106559 | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | 0.458 |
Gml | Cnpy4 | ENSMUSP00000094131 | ENSMUSP00000106559 | Glycosylphosphatidylinositol-anchored molecule-like. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | 0.550 |
Gml | Lrig3 | ENSMUSP00000094131 | ENSMUSP00000074360 | Glycosylphosphatidylinositol-anchored molecule-like. | Leucine-rich repeats and immunoglobulin-like domains protein 3; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. | 0.547 |
Gml | Lrrc40 | ENSMUSP00000094131 | ENSMUSP00000071956 | Glycosylphosphatidylinositol-anchored molecule-like. | Leucine-rich repeat-containing protein 40. | 0.612 |
Hsp90b1 | Cnpy2 | ENSMUSP00000020238 | ENSMUSP00000151918 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family. | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | 0.417 |
Hsp90b1 | Cnpy4 | ENSMUSP00000020238 | ENSMUSP00000106559 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family. | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family. | 0.538 |
Hsp90b1 | Tlr4 | ENSMUSP00000020238 | ENSMUSP00000045770 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding t [...] | 0.984 |