STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tmem248Transmembrane protein 248. (314 aa)    
Predicted Functional Partners:
2700097O09Rik
RIKEN cDNA 2700097O09 gene.
   
  
 0.663
Rabgef1
Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity).
 
 
  
 0.623
Lrrc72
Leucine-rich repeat-containing 72.
      
 0.608
Adam26a
Disintegrin and metalloproteinase domain-containing protein 26A; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization.
      
 0.521
Ccdc116
Coiled-coil domain-containing protein 116.
      
 0.518
Purb
Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VS [...]
   
  
 0.513
Arl10
ADP-ribosylation factor-like protein 10; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.499
Tmem256
Transmembrane protein 256.
   
  
 0.494
Plpp6
Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). Belongs to the PA-phosphatase related phosphoesterase family.
   
  
 0.489
Iqub
IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance.
      
 0.489
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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