node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btbd10 | Kctd12b | ENSMUSP00000048530 | ENSMUSP00000108191 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | Potassium channel tetramerisation domain-containing 12b. | 0.571 |
Btbd10 | Kctd19 | ENSMUSP00000048530 | ENSMUSP00000050687 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | BTB/POZ domain-containing protein KCTD19. | 0.651 |
Gabbr1 | Gabbr2 | ENSMUSP00000025338 | ENSMUSP00000103378 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | 0.999 |
Gabbr1 | Kctd12b | ENSMUSP00000025338 | ENSMUSP00000108191 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | Potassium channel tetramerisation domain-containing 12b. | 0.573 |
Gabbr2 | Gabbr1 | ENSMUSP00000103378 | ENSMUSP00000025338 | Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | 0.999 |
Gabbr2 | Kctd12b | ENSMUSP00000103378 | ENSMUSP00000108191 | Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | Potassium channel tetramerisation domain-containing 12b. | 0.505 |
Kctd11 | Kctd12b | ENSMUSP00000159163 | ENSMUSP00000108191 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | Potassium channel tetramerisation domain-containing 12b. | 0.493 |
Kctd12b | Btbd10 | ENSMUSP00000108191 | ENSMUSP00000048530 | Potassium channel tetramerisation domain-containing 12b. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.571 |
Kctd12b | Gabbr1 | ENSMUSP00000108191 | ENSMUSP00000025338 | Potassium channel tetramerisation domain-containing 12b. | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | 0.573 |
Kctd12b | Gabbr2 | ENSMUSP00000108191 | ENSMUSP00000103378 | Potassium channel tetramerisation domain-containing 12b. | Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] | 0.505 |
Kctd12b | Kctd11 | ENSMUSP00000108191 | ENSMUSP00000159163 | Potassium channel tetramerisation domain-containing 12b. | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of [...] | 0.493 |
Kctd12b | Kctd19 | ENSMUSP00000108191 | ENSMUSP00000050687 | Potassium channel tetramerisation domain-containing 12b. | BTB/POZ domain-containing protein KCTD19. | 0.530 |
Kctd12b | Zfp566 | ENSMUSP00000108191 | ENSMUSP00000086164 | Potassium channel tetramerisation domain-containing 12b. | Zinc finger protein 566. | 0.510 |
Kctd19 | Btbd10 | ENSMUSP00000050687 | ENSMUSP00000048530 | BTB/POZ domain-containing protein KCTD19. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells. | 0.651 |
Kctd19 | Kctd12b | ENSMUSP00000050687 | ENSMUSP00000108191 | BTB/POZ domain-containing protein KCTD19. | Potassium channel tetramerisation domain-containing 12b. | 0.530 |
Zfp566 | Kctd12b | ENSMUSP00000086164 | ENSMUSP00000108191 | Zinc finger protein 566. | Potassium channel tetramerisation domain-containing 12b. | 0.510 |