node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1700013F07Rik | Nek10 | ENSMUSP00000029485 | ENSMUSP00000153142 | Protein C1orf194 homolog; May play an important role for the maintenance of myelin-axon integrity. May affect intracellular Ca(2+) homeostasis (By similarity). | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.452 |
Map2k1 | Nek10 | ENSMUSP00000005066 | ENSMUSP00000153142 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.446 |
Mcc | Nek10 | ENSMUSP00000087318 | ENSMUSP00000153142 | Mutated in colorectal cancers. | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.477 |
Mcc | Nwd2 | ENSMUSP00000087318 | ENSMUSP00000124712 | Mutated in colorectal cancers. | NACHT and WD repeat domain-containing protein 2. | 0.499 |
Nek10 | 1700013F07Rik | ENSMUSP00000153142 | ENSMUSP00000029485 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Protein C1orf194 homolog; May play an important role for the maintenance of myelin-axon integrity. May affect intracellular Ca(2+) homeostasis (By similarity). | 0.452 |
Nek10 | Map2k1 | ENSMUSP00000153142 | ENSMUSP00000005066 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | 0.446 |
Nek10 | Mcc | ENSMUSP00000153142 | ENSMUSP00000087318 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Mutated in colorectal cancers. | 0.477 |
Nek10 | Nwd2 | ENSMUSP00000153142 | ENSMUSP00000124712 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | NACHT and WD repeat domain-containing protein 2. | 0.454 |
Nek10 | Prkdc | ENSMUSP00000153142 | ENSMUSP00000023352 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step [...] | 0.471 |
Nek10 | Slc4a7 | ENSMUSP00000153142 | ENSMUSP00000058313 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity; Belongs to the anion exchanger (TC 2.A.31) family. | 0.567 |
Nek10 | Sumo1 | ENSMUSP00000153142 | ENSMUSP00000088935 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.453 |
Nek10 | Tox3 | ENSMUSP00000153142 | ENSMUSP00000105250 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region (By similarity). | 0.523 |
Nek10 | Ube2i | ENSMUSP00000153142 | ENSMUSP00000134169 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By si [...] | 0.443 |
Nek10 | Vwa8 | ENSMUSP00000153142 | ENSMUSP00000048925 | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro. | 0.506 |
Nwd2 | Mcc | ENSMUSP00000124712 | ENSMUSP00000087318 | NACHT and WD repeat domain-containing protein 2. | Mutated in colorectal cancers. | 0.499 |
Nwd2 | Nek10 | ENSMUSP00000124712 | ENSMUSP00000153142 | NACHT and WD repeat domain-containing protein 2. | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.454 |
Prkdc | Nek10 | ENSMUSP00000023352 | ENSMUSP00000153142 | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step [...] | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.471 |
Slc4a7 | Nek10 | ENSMUSP00000058313 | ENSMUSP00000153142 | Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity; Belongs to the anion exchanger (TC 2.A.31) family. | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.567 |
Slc4a7 | Tox3 | ENSMUSP00000058313 | ENSMUSP00000105250 | Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity; Belongs to the anion exchanger (TC 2.A.31) family. | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region (By similarity). | 0.465 |
Sumo1 | Nek10 | ENSMUSP00000088935 | ENSMUSP00000153142 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.453 |