node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ambn | Amelx | ENSMUSP00000142944 | ENSMUSP00000065966 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.992 |
Ambn | Amtn | ENSMUSP00000142944 | ENSMUSP00000073081 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.961 |
Ambn | Enam | ENSMUSP00000142944 | ENSMUSP00000031222 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.991 |
Ambn | Gm17660 | ENSMUSP00000142944 | ENSMUSP00000143623 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Secretory calcium-binding phosphoprotein proline-glutamine rich 1 variant 1. | 0.540 |
Ambn | Ibsp | ENSMUSP00000142944 | ENSMUSP00000031246 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). | 0.615 |
Ambn | Klk1b4 | ENSMUSP00000142944 | ENSMUSP00000076576 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein 1-related peptidase-like b4. | 0.792 |
Ambn | Klk4 | ENSMUSP00000142944 | ENSMUSP00000007161 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.874 |
Ambn | Mepe | ENSMUSP00000142944 | ENSMUSP00000065200 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Matrix extracellular phosphoglycoprotein; Regulates renal phosphate and uric acid excretion. Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Increases dental pulp stem cell proliferation (By similarity). Belongs to the PF07175/osteoregulin family. | 0.581 |
Ambn | Mmp20 | ENSMUSP00000142944 | ENSMUSP00000034487 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.872 |
Ambn | Odam | ENSMUSP00000142944 | ENSMUSP00000117898 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.752 |
Amelx | Ambn | ENSMUSP00000065966 | ENSMUSP00000142944 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Ameloblastin; Involved in the mineralization and structural organization of enamel. | 0.992 |
Amelx | Amtn | ENSMUSP00000065966 | ENSMUSP00000073081 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.911 |
Amelx | Enam | ENSMUSP00000065966 | ENSMUSP00000031222 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.990 |
Amelx | Gm17660 | ENSMUSP00000065966 | ENSMUSP00000143623 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Secretory calcium-binding phosphoprotein proline-glutamine rich 1 variant 1. | 0.552 |
Amelx | Ibsp | ENSMUSP00000065966 | ENSMUSP00000031246 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity). | 0.621 |
Amelx | Klk1b4 | ENSMUSP00000065966 | ENSMUSP00000076576 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein 1-related peptidase-like b4. | 0.802 |
Amelx | Klk4 | ENSMUSP00000065966 | ENSMUSP00000007161 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.917 |
Amelx | Mepe | ENSMUSP00000065966 | ENSMUSP00000065200 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Matrix extracellular phosphoglycoprotein; Regulates renal phosphate and uric acid excretion. Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Increases dental pulp stem cell proliferation (By similarity). Belongs to the PF07175/osteoregulin family. | 0.509 |
Amelx | Mmp20 | ENSMUSP00000065966 | ENSMUSP00000034487 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. | 0.923 |
Amelx | Odam | ENSMUSP00000065966 | ENSMUSP00000117898 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. | 0.732 |