node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asic3 | Prdm12 | ENSMUSP00000143083 | ENSMUSP00000109098 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.441 |
Asic3 | Trpv1 | ENSMUSP00000143083 | ENSMUSP00000099585 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] | 0.835 |
Dbx1 | Neurog1 | ENSMUSP00000032717 | ENSMUSP00000050484 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | 0.533 |
Dbx1 | Prdm12 | ENSMUSP00000032717 | ENSMUSP00000109098 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.440 |
En1 | Prdm12 | ENSMUSP00000078659 | ENSMUSP00000109098 | Homeobox protein engrailed-1. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.445 |
Gm765 | Prdm12 | ENSMUSP00000127120 | ENSMUSP00000109098 | Gene model 765, (NCBI). | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.453 |
Gpr101 | Prdm12 | ENSMUSP00000058183 | ENSMUSP00000109098 | Probable G-protein coupled receptor 101; Orphan receptor. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.451 |
Neurod2 | Prdm12 | ENSMUSP00000041373 | ENSMUSP00000109098 | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.446 |
Neurog1 | Dbx1 | ENSMUSP00000050484 | ENSMUSP00000032717 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | 0.533 |
Neurog1 | Phox2b | ENSMUSP00000050484 | ENSMUSP00000012664 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | Paired mesoderm homeobox protein 2B; Belongs to the paired homeobox family. | 0.511 |
Neurog1 | Prdm12 | ENSMUSP00000050484 | ENSMUSP00000109098 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.582 |
Phox2b | Neurog1 | ENSMUSP00000012664 | ENSMUSP00000050484 | Paired mesoderm homeobox protein 2B; Belongs to the paired homeobox family. | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | 0.511 |
Phox2b | Prdm12 | ENSMUSP00000012664 | ENSMUSP00000109098 | Paired mesoderm homeobox protein 2B; Belongs to the paired homeobox family. | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | 0.496 |
Prdm12 | Asic3 | ENSMUSP00000109098 | ENSMUSP00000143083 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. | 0.441 |
Prdm12 | Dbx1 | ENSMUSP00000109098 | ENSMUSP00000032717 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | 0.440 |
Prdm12 | En1 | ENSMUSP00000109098 | ENSMUSP00000078659 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Homeobox protein engrailed-1. | 0.445 |
Prdm12 | Gm765 | ENSMUSP00000109098 | ENSMUSP00000127120 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Gene model 765, (NCBI). | 0.453 |
Prdm12 | Gpr101 | ENSMUSP00000109098 | ENSMUSP00000058183 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.451 |
Prdm12 | Neurod2 | ENSMUSP00000109098 | ENSMUSP00000041373 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] | 0.446 |
Prdm12 | Neurog1 | ENSMUSP00000109098 | ENSMUSP00000050484 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation. | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. | 0.582 |