node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fancm | Pnma5 | ENSMUSP00000054797 | ENSMUSP00000063061 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Paraneoplastic antigen-like protein 5. | 0.679 |
Fancm | Pnmal1 | ENSMUSP00000054797 | ENSMUSP00000040929 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | 0.680 |
Fancm | Rtl4 | ENSMUSP00000054797 | ENSMUSP00000108462 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | 0.679 |
Fancm | Rtl5 | ENSMUSP00000054797 | ENSMUSP00000109261 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Retrotransposon Gag-like protein 5. | 0.679 |
Fancm | Rtl8a | ENSMUSP00000054797 | ENSMUSP00000086158 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Retrotransposon Gag like 8A. | 0.679 |
Fancm | Rtl8b | ENSMUSP00000054797 | ENSMUSP00000086157 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | CAAX box 1 homolog A (Human). | 0.679 |
Fancm | Rtl8c | ENSMUSP00000054797 | ENSMUSP00000069901 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Retrotransposon Gag-like 8C. | 0.679 |
Fancm | Zbed5 | ENSMUSP00000054797 | ENSMUSP00000044533 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Zinc finger, BED type-containing 5. | 0.815 |
Fancm | Zcchc12 | ENSMUSP00000054797 | ENSMUSP00000110911 | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression. | 0.679 |
Pnma5 | Fancm | ENSMUSP00000063061 | ENSMUSP00000054797 | Paraneoplastic antigen-like protein 5. | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | 0.679 |
Pnma5 | Rtl5 | ENSMUSP00000063061 | ENSMUSP00000109261 | Paraneoplastic antigen-like protein 5. | Retrotransposon Gag-like protein 5. | 0.474 |
Pnma5 | Zbed5 | ENSMUSP00000063061 | ENSMUSP00000044533 | Paraneoplastic antigen-like protein 5. | Zinc finger, BED type-containing 5. | 0.484 |
Pnmal1 | Fancm | ENSMUSP00000040929 | ENSMUSP00000054797 | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | 0.680 |
Pnmal1 | Rtl4 | ENSMUSP00000040929 | ENSMUSP00000108462 | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | 0.590 |
Pnmal1 | Rtl5 | ENSMUSP00000040929 | ENSMUSP00000109261 | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | Retrotransposon Gag-like protein 5. | 0.505 |
Pnmal1 | Zcchc12 | ENSMUSP00000040929 | ENSMUSP00000110911 | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression. | 0.713 |
Rtl4 | Fancm | ENSMUSP00000108462 | ENSMUSP00000054797 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] | 0.679 |
Rtl4 | Pnmal1 | ENSMUSP00000108462 | ENSMUSP00000040929 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family. | 0.590 |
Rtl4 | Rtl5 | ENSMUSP00000108462 | ENSMUSP00000109261 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon Gag-like protein 5. | 0.677 |
Rtl4 | Rtl8a | ENSMUSP00000108462 | ENSMUSP00000086158 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon Gag like 8A. | 0.487 |