node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr10 | Actr1a | ENSMUSP00000021479 | ENSMUSP00000039844 | Actin-related protein 10; Belongs to the actin family. | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | 0.998 |
Actr10 | Clip1 | ENSMUSP00000021479 | ENSMUSP00000107192 | Actin-related protein 10; Belongs to the actin family. | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | 0.504 |
Actr10 | Dctn1 | ENSMUSP00000021479 | ENSMUSP00000109552 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.998 |
Actr10 | Dctn2 | ENSMUSP00000021479 | ENSMUSP00000026479 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr10 | Dctn3 | ENSMUSP00000021479 | ENSMUSP00000030158 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.994 |
Actr10 | Dctn4 | ENSMUSP00000021479 | ENSMUSP00000025505 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.999 |
Actr10 | Dctn5 | ENSMUSP00000021479 | ENSMUSP00000033156 | Actin-related protein 10; Belongs to the actin family. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.999 |
Actr10 | Dync1h1 | ENSMUSP00000021479 | ENSMUSP00000018851 | Actin-related protein 10; Belongs to the actin family. | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. | 0.817 |
Actr10 | Dync1i1 | ENSMUSP00000021479 | ENSMUSP00000111221 | Actin-related protein 10; Belongs to the actin family. | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] | 0.825 |
Actr10 | Hap1 | ENSMUSP00000021479 | ENSMUSP00000133356 | Actin-related protein 10; Belongs to the actin family. | Huntingtin-associated protein 1; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via associati [...] | 0.828 |
Actr1a | Actr10 | ENSMUSP00000039844 | ENSMUSP00000021479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Actin-related protein 10; Belongs to the actin family. | 0.998 |
Actr1a | Dctn1 | ENSMUSP00000039844 | ENSMUSP00000109552 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] | 0.995 |
Actr1a | Dctn2 | ENSMUSP00000039844 | ENSMUSP00000026479 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family. | 0.999 |
Actr1a | Dctn3 | ENSMUSP00000039844 | ENSMUSP00000030158 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis. | 0.992 |
Actr1a | Dctn4 | ENSMUSP00000039844 | ENSMUSP00000025505 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.997 |
Actr1a | Dctn5 | ENSMUSP00000039844 | ENSMUSP00000033156 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. | 0.995 |
Actr1a | Dync1h1 | ENSMUSP00000039844 | ENSMUSP00000018851 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. | 0.973 |
Actr1a | Dync1i1 | ENSMUSP00000039844 | ENSMUSP00000111221 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] | 0.660 |
Actr1a | Hap1 | ENSMUSP00000039844 | ENSMUSP00000133356 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. | Huntingtin-associated protein 1; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via associati [...] | 0.816 |
Clip1 | Actr10 | ENSMUSP00000107192 | ENSMUSP00000021479 | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. | Actin-related protein 10; Belongs to the actin family. | 0.504 |