STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Zdbf2DBF4-type zinc finger-containing protein 2 homolog. (2493 aa)    
Predicted Functional Partners:
Gpr1
G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.
   
  
 0.756
Fam50b
Protein FAM50B.
      
 0.660
Peg10
Retrotransposon-derived protein PEG10; May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
   
  
 0.641
Snrpn
Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events.
   
  
 0.633
Dlk1
Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.
   
  
 0.625
Mest
Mesoderm-specific transcript protein; Belongs to the AB hydrolase superfamily.
   
  
 0.623
Zfp445
Zinc finger protein 445; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, ZNF445 seems to be the major factor in human early embryonic imprintin [...]
      
 0.619
Rasgrf1
Ras-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP.
   
  
 0.617
Nap1l5
Nucleosome assembly protein 1-like 5.
   
  
 0.588
Zrsr1
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; Plays a role in splicing of the U12-type introns. Implicated also in removal of U2 introns positioned adjacent to a U12 intron.
      
 0.575
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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