node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cldn3 | Plet1 | ENSMUSP00000091799 | ENSMUSP00000110118 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.467 |
Cldn3 | Psmb11 | ENSMUSP00000091799 | ENSMUSP00000132140 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells; Belongs to the peptidase T1B family. | 0.439 |
Elf5 | Plet1 | ENSMUSP00000126941 | ENSMUSP00000110118 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.472 |
Enpep | Foxn1 | ENSMUSP00000029658 | ENSMUSP00000103929 | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | 0.604 |
Enpep | Foxn2 | ENSMUSP00000029658 | ENSMUSP00000107857 | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | Forkhead box N2. | 0.577 |
Enpep | Plet1 | ENSMUSP00000029658 | ENSMUSP00000110118 | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.496 |
Enpep | Psmb11 | ENSMUSP00000029658 | ENSMUSP00000132140 | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells; Belongs to the peptidase T1B family. | 0.716 |
Foxn1 | Enpep | ENSMUSP00000103929 | ENSMUSP00000029658 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | 0.604 |
Foxn1 | Plet1 | ENSMUSP00000103929 | ENSMUSP00000110118 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.536 |
Foxn1 | Psmb11 | ENSMUSP00000103929 | ENSMUSP00000132140 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells; Belongs to the peptidase T1B family. | 0.728 |
Foxn2 | Enpep | ENSMUSP00000107857 | ENSMUSP00000029658 | Forkhead box N2. | Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. | 0.577 |
Foxn2 | Plet1 | ENSMUSP00000107857 | ENSMUSP00000110118 | Forkhead box N2. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.491 |
Foxn2 | Psmb11 | ENSMUSP00000107857 | ENSMUSP00000132140 | Forkhead box N2. | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells; Belongs to the peptidase T1B family. | 0.698 |
Krt15 | Krt79 | ENSMUSP00000103034 | ENSMUSP00000023799 | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. | Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. | 0.435 |
Krt15 | Lgr6 | ENSMUSP00000103034 | ENSMUSP00000035444 | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. | Leucine-rich repeat-containing G-protein coupled receptor 6; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity). | 0.672 |
Krt15 | Lrig1 | ENSMUSP00000103034 | ENSMUSP00000098686 | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.662 |
Krt15 | Plet1 | ENSMUSP00000103034 | ENSMUSP00000110118 | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.496 |
Krt79 | Krt15 | ENSMUSP00000023799 | ENSMUSP00000103034 | Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. | Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family. | 0.435 |
Krt79 | Lrig1 | ENSMUSP00000023799 | ENSMUSP00000098686 | Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. | 0.702 |
Krt79 | Plet1 | ENSMUSP00000023799 | ENSMUSP00000110118 | Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family. | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. | 0.481 |