Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Transmembrane protein 182 (229 aa)
Predicted Functional Partners:
Transmembrane 6 superfamily member 1; May function as sterol isomerase (370 aa)
Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization (By similarity); Belongs to the tropomodulin family (571 aa)
Tetraspanin-33; Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity) (283 aa)
Ubiquilin-3; Ubiquilin 3 (658 aa)
Tumor protein p63-regulated gene 1 protein; Transformation related protein 63 regulated (279 aa)
Myosin light chain 1/3, skeletal muscle isoform; Regulatory light chain of myosin. Does not bind calcium (188 aa)
Small integral membrane protein 23 (136 aa)
Histidine rich calcium binding protein (738 aa)
LIM domain-binding protein 3; May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton (723 aa)
Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair (85 aa)
Your Current Organism:
NCBI taxonomy Id: 10090 Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice