node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgra3 | Dusp7 | ENSMUSP00000030971 | ENSMUSP00000126984 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to [...] | 0.564 |
Adgra3 | Fam171a1 | ENSMUSP00000030971 | ENSMUSP00000110751 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | Family with sequence similarity 171, member A1. | 0.487 |
Adgra3 | Unkl | ENSMUSP00000030971 | ENSMUSP00000039670 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family. | 0.551 |
Avpr1a | Fam171a1 | ENSMUSP00000020323 | ENSMUSP00000110751 | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. | Family with sequence similarity 171, member A1. | 0.443 |
Camkk1 | Fam171a1 | ENSMUSP00000090613 | ENSMUSP00000110751 | Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. | Family with sequence similarity 171, member A1. | 0.525 |
Camkk1 | Unkl | ENSMUSP00000090613 | ENSMUSP00000039670 | Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family. | 0.447 |
Ddr2 | Fam171a1 | ENSMUSP00000141443 | ENSMUSP00000110751 | Discoidin domain-containing receptor 2; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migra [...] | Family with sequence similarity 171, member A1. | 0.402 |
Dusp7 | Adgra3 | ENSMUSP00000126984 | ENSMUSP00000030971 | Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to [...] | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | 0.564 |
Dusp7 | Fam171a1 | ENSMUSP00000126984 | ENSMUSP00000110751 | Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to [...] | Family with sequence similarity 171, member A1. | 0.485 |
Fam171a1 | Adgra3 | ENSMUSP00000110751 | ENSMUSP00000030971 | Family with sequence similarity 171, member A1. | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | 0.487 |
Fam171a1 | Avpr1a | ENSMUSP00000110751 | ENSMUSP00000020323 | Family with sequence similarity 171, member A1. | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. | 0.443 |
Fam171a1 | Camkk1 | ENSMUSP00000110751 | ENSMUSP00000090613 | Family with sequence similarity 171, member A1. | Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. | 0.525 |
Fam171a1 | Ddr2 | ENSMUSP00000110751 | ENSMUSP00000141443 | Family with sequence similarity 171, member A1. | Discoidin domain-containing receptor 2; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migra [...] | 0.402 |
Fam171a1 | Dusp7 | ENSMUSP00000110751 | ENSMUSP00000126984 | Family with sequence similarity 171, member A1. | Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to [...] | 0.485 |
Fam171a1 | Rassf10 | ENSMUSP00000110751 | ENSMUSP00000138103 | Family with sequence similarity 171, member A1. | Ras association domain-containing protein 10; Plays an important role in regulating embryonic neurogenesis. | 0.611 |
Fam171a1 | Unkl | ENSMUSP00000110751 | ENSMUSP00000039670 | Family with sequence similarity 171, member A1. | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family. | 0.712 |
Fam171a1 | Zcchc24 | ENSMUSP00000110751 | ENSMUSP00000068677 | Family with sequence similarity 171, member A1. | Zinc finger CCHC domain-containing protein 24. | 0.433 |
Rassf10 | Fam171a1 | ENSMUSP00000138103 | ENSMUSP00000110751 | Ras association domain-containing protein 10; Plays an important role in regulating embryonic neurogenesis. | Family with sequence similarity 171, member A1. | 0.611 |
Unkl | Adgra3 | ENSMUSP00000039670 | ENSMUSP00000030971 | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family. | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway. | 0.551 |
Unkl | Camkk1 | ENSMUSP00000039670 | ENSMUSP00000090613 | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family. | Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death. | 0.447 |