node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
2510039O18Rik | Pdxdc1 | ENSMUSP00000099522 | ENSMUSP00000023361 | Uncharacterized protein KIAA2013. | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.525 |
Bahd1 | Pdxdc1 | ENSMUSP00000043130 | ENSMUSP00000023361 | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.566 |
Bahd1 | Ppp1r35 | ENSMUSP00000043130 | ENSMUSP00000031739 | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). | Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity; Belongs to the PPP1R35 family. | 0.661 |
Bfar | Pdxdc1 | ENSMUSP00000023365 | ENSMUSP00000023361 | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.609 |
Ccdc6 | Pdxdc1 | ENSMUSP00000123374 | ENSMUSP00000023361 | Coiled-coil domain-containing protein 6. | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.525 |
Marf1 | Mpv17l | ENSMUSP00000087770 | ENSMUSP00000023360 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | 0.656 |
Marf1 | Ntan1 | ENSMUSP00000087770 | ENSMUSP00000023362 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | 0.473 |
Marf1 | Pdxdc1 | ENSMUSP00000087770 | ENSMUSP00000023361 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.504 |
Marf1 | Rrn3 | ENSMUSP00000087770 | ENSMUSP00000023363 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family. | 0.588 |
Mpv17l | Marf1 | ENSMUSP00000023360 | ENSMUSP00000087770 | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | 0.656 |
Mpv17l | Ntan1 | ENSMUSP00000023360 | ENSMUSP00000023362 | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | 0.421 |
Mpv17l | Pdxdc1 | ENSMUSP00000023360 | ENSMUSP00000023361 | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.580 |
Mpv17l | Rrn3 | ENSMUSP00000023360 | ENSMUSP00000023363 | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family. | 0.622 |
Ntan1 | Marf1 | ENSMUSP00000023362 | ENSMUSP00000087770 | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks. | 0.473 |
Ntan1 | Mpv17l | ENSMUSP00000023362 | ENSMUSP00000023360 | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family. | 0.421 |
Ntan1 | Pdxdc1 | ENSMUSP00000023362 | ENSMUSP00000023361 | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | 0.675 |
Ntan1 | Rrn3 | ENSMUSP00000023362 | ENSMUSP00000023363 | Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family. | 0.668 |
Pdxdc1 | 2510039O18Rik | ENSMUSP00000023361 | ENSMUSP00000099522 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | Uncharacterized protein KIAA2013. | 0.525 |
Pdxdc1 | Bahd1 | ENSMUSP00000023361 | ENSMUSP00000043130 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). | 0.566 |
Pdxdc1 | Bfar | ENSMUSP00000023361 | ENSMUSP00000023365 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family. | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). | 0.609 |