STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prss53Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Belongs to the peptidase S1 family. (552 aa)    
Predicted Functional Partners:
Fbxl19
F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (By similarity).
      
 0.562
Tchhl1
Trichohyalin-like protein 1; Belongs to the S-100 family.
   
 
 0.549
Zfp646
Zinc finger protein 646; May be involved in transcriptional regulation.
  
   
 0.535
Tmem229b
Transmembrane protein 229B.
      
 0.511
Prr14
Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (By similarity). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferatio [...]
      
 0.496
Sumf2
Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family.
    
 
 0.488
Ttc28
Tetratricopeptide repeat protein 28; During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
    
 
 0.481
Kctd7
BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.
      
 0.457
Zfp629
Zinc finger protein 629; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.456
Krtap17-1
Keratin-associated protein 17-1.
   
  
 0.448
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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