node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abhd10 | Abhd13 | ENSMUSP00000065282 | ENSMUSP00000116130 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Protein ABHD13. | 0.577 |
Abhd10 | Abhd17c | ENSMUSP00000065282 | ENSMUSP00000112988 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | 0.495 |
Abhd10 | Lypla1 | ENSMUSP00000065282 | ENSMUSP00000027036 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity); Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.570 |
Abhd10 | Lypla2 | ENSMUSP00000065282 | ENSMUSP00000064204 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.545 |
Abhd10 | Lyplal1 | ENSMUSP00000065282 | ENSMUSP00000048229 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 0.449 |
Abhd10 | Ppt1 | ENSMUSP00000065282 | ENSMUSP00000030412 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.518 |
Abhd10 | Ppt2 | ENSMUSP00000065282 | ENSMUSP00000131243 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). | 0.496 |
Abhd13 | Abhd10 | ENSMUSP00000116130 | ENSMUSP00000065282 | Protein ABHD13. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | 0.577 |
Abhd13 | Abhd17c | ENSMUSP00000116130 | ENSMUSP00000112988 | Protein ABHD13. | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | 0.536 |
Abhd13 | Lypla1 | ENSMUSP00000116130 | ENSMUSP00000027036 | Protein ABHD13. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity); Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.646 |
Abhd13 | Lypla2 | ENSMUSP00000116130 | ENSMUSP00000064204 | Protein ABHD13. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.606 |
Abhd13 | Lyplal1 | ENSMUSP00000116130 | ENSMUSP00000048229 | Protein ABHD13. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 0.554 |
Abhd17c | Abhd10 | ENSMUSP00000112988 | ENSMUSP00000065282 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial. | 0.495 |
Abhd17c | Abhd13 | ENSMUSP00000112988 | ENSMUSP00000116130 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | Protein ABHD13. | 0.536 |
Abhd17c | Hras | ENSMUSP00000112988 | ENSMUSP00000026572 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. | 0.575 |
Abhd17c | Kras | ENSMUSP00000112988 | ENSMUSP00000032399 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity). | 0.573 |
Abhd17c | Lypla1 | ENSMUSP00000112988 | ENSMUSP00000027036 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity); Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.699 |
Abhd17c | Lypla2 | ENSMUSP00000112988 | ENSMUSP00000064204 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.475 |
Abhd17c | Lyplal1 | ENSMUSP00000112988 | ENSMUSP00000048229 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity). | 0.577 |
Abhd17c | Nras | ENSMUSP00000112988 | ENSMUSP00000029445 | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.646 |