node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aktip | Fam160a1 | ENSMUSP00000112375 | ENSMUSP00000113235 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). | Protein FAM160A1; Belongs to the UPF0518 family. | 0.838 |
Aktip | Fam160b1 | ENSMUSP00000112375 | ENSMUSP00000048903 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). | Protein FAM160B1. | 0.595 |
Aktip | Hook3 | ENSMUSP00000112375 | ENSMUSP00000046788 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). | Protein Hook homolog 3; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Acts as an adapter protein linking the dynein motor complex to [...] | 0.974 |
Brinp1 | Fam160a1 | ENSMUSP00000030036 | ENSMUSP00000113235 | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway; Belongs to the BRINP family. | Protein FAM160A1; Belongs to the UPF0518 family. | 0.594 |
Brinp1 | Gpr26 | ENSMUSP00000030036 | ENSMUSP00000041664 | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway; Belongs to the BRINP family. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.607 |
Brinp1 | Lrig3 | ENSMUSP00000030036 | ENSMUSP00000074360 | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway; Belongs to the BRINP family. | Leucine-rich repeats and immunoglobulin-like domains protein 3; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. | 0.466 |
Brinp1 | Wdr35 | ENSMUSP00000030036 | ENSMUSP00000082895 | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway; Belongs to the BRINP family. | WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). | 0.484 |
Fam160a1 | Aktip | ENSMUSP00000113235 | ENSMUSP00000112375 | Protein FAM160A1; Belongs to the UPF0518 family. | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). | 0.838 |
Fam160a1 | Brinp1 | ENSMUSP00000113235 | ENSMUSP00000030036 | Protein FAM160A1; Belongs to the UPF0518 family. | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway; Belongs to the BRINP family. | 0.594 |
Fam160a1 | Fam160b1 | ENSMUSP00000113235 | ENSMUSP00000048903 | Protein FAM160A1; Belongs to the UPF0518 family. | Protein FAM160B1. | 0.673 |
Fam160a1 | Gpr26 | ENSMUSP00000113235 | ENSMUSP00000041664 | Protein FAM160A1; Belongs to the UPF0518 family. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.609 |
Fam160a1 | Gulp1 | ENSMUSP00000113235 | ENSMUSP00000074115 | Protein FAM160A1; Belongs to the UPF0518 family. | PTB domain-containing engulfment adapter protein 1; Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6. | 0.530 |
Fam160a1 | Hook3 | ENSMUSP00000113235 | ENSMUSP00000046788 | Protein FAM160A1; Belongs to the UPF0518 family. | Protein Hook homolog 3; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Acts as an adapter protein linking the dynein motor complex to [...] | 0.745 |
Fam160a1 | Lrig3 | ENSMUSP00000113235 | ENSMUSP00000074360 | Protein FAM160A1; Belongs to the UPF0518 family. | Leucine-rich repeats and immunoglobulin-like domains protein 3; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. | 0.515 |
Fam160a1 | Lzts2 | ENSMUSP00000113235 | ENSMUSP00000045478 | Protein FAM160A1; Belongs to the UPF0518 family. | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. | 0.659 |
Fam160a1 | Sipa1l1 | ENSMUSP00000113235 | ENSMUSP00000131030 | Protein FAM160A1; Belongs to the UPF0518 family. | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). | 0.551 |
Fam160a1 | Wdr35 | ENSMUSP00000113235 | ENSMUSP00000082895 | Protein FAM160A1; Belongs to the UPF0518 family. | WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). | 0.547 |
Fam160b1 | Aktip | ENSMUSP00000048903 | ENSMUSP00000112375 | Protein FAM160B1. | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity). | 0.595 |
Fam160b1 | Fam160a1 | ENSMUSP00000048903 | ENSMUSP00000113235 | Protein FAM160B1. | Protein FAM160A1; Belongs to the UPF0518 family. | 0.673 |
Fam160b1 | Hook3 | ENSMUSP00000048903 | ENSMUSP00000046788 | Protein FAM160B1. | Protein Hook homolog 3; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Acts as an adapter protein linking the dynein motor complex to [...] | 0.781 |