node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Espnl | Olfr368 | ENSMUSP00000086294 | ENSMUSP00000149348 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | Olfactory receptor. | 0.511 |
Espnl | Tmem229a | ENSMUSP00000086294 | ENSMUSP00000116234 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | Transmembrane protein 229A. | 0.442 |
Kif27 | Tmem229a | ENSMUSP00000153598 | ENSMUSP00000116234 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis. | Transmembrane protein 229A. | 0.549 |
Ndc1 | Tmem229a | ENSMUSP00000120365 | ENSMUSP00000116234 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. | Transmembrane protein 229A. | 0.410 |
Ndc1 | Tmem98 | ENSMUSP00000120365 | ENSMUSP00000042825 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.407 |
Olfr368 | Espnl | ENSMUSP00000149348 | ENSMUSP00000086294 | Olfactory receptor. | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | 0.511 |
Olfr368 | Tmem229a | ENSMUSP00000149348 | ENSMUSP00000116234 | Olfactory receptor. | Transmembrane protein 229A. | 0.641 |
Sike1 | Tmem229a | ENSMUSP00000029447 | ENSMUSP00000116234 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Transmembrane protein 229A. | 0.445 |
Tmem106a | Tmem209 | ENSMUSP00000097971 | ENSMUSP00000110813 | Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration (By similarity); Belongs to the TMEM106 family. | Transmembrane protein 209. | 0.428 |
Tmem106a | Tmem229a | ENSMUSP00000097971 | ENSMUSP00000116234 | Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration (By similarity); Belongs to the TMEM106 family. | Transmembrane protein 229A. | 0.452 |
Tmem106a | Tmem98 | ENSMUSP00000097971 | ENSMUSP00000042825 | Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration (By similarity); Belongs to the TMEM106 family. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.409 |
Tmem209 | Tmem106a | ENSMUSP00000110813 | ENSMUSP00000097971 | Transmembrane protein 209. | Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration (By similarity); Belongs to the TMEM106 family. | 0.428 |
Tmem209 | Tmem229a | ENSMUSP00000110813 | ENSMUSP00000116234 | Transmembrane protein 209. | Transmembrane protein 229A. | 0.479 |
Tmem229a | Espnl | ENSMUSP00000116234 | ENSMUSP00000086294 | Transmembrane protein 229A. | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | 0.442 |
Tmem229a | Kif27 | ENSMUSP00000116234 | ENSMUSP00000153598 | Transmembrane protein 229A. | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis. | 0.549 |
Tmem229a | Ndc1 | ENSMUSP00000116234 | ENSMUSP00000120365 | Transmembrane protein 229A. | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. | 0.410 |
Tmem229a | Olfr368 | ENSMUSP00000116234 | ENSMUSP00000149348 | Transmembrane protein 229A. | Olfactory receptor. | 0.641 |
Tmem229a | Sike1 | ENSMUSP00000116234 | ENSMUSP00000029447 | Transmembrane protein 229A. | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | 0.445 |
Tmem229a | Tmem106a | ENSMUSP00000116234 | ENSMUSP00000097971 | Transmembrane protein 229A. | Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration (By similarity); Belongs to the TMEM106 family. | 0.452 |
Tmem229a | Tmem209 | ENSMUSP00000116234 | ENSMUSP00000110813 | Transmembrane protein 229A. | Transmembrane protein 209. | 0.479 |