node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clcn6 | D630045J12Rik | ENSMUSP00000030879 | ENSMUSP00000130121 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | 0.493 |
Clcn6 | Fam131b | ENSMUSP00000030879 | ENSMUSP00000116779 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | Protein FAM131B. | 0.727 |
Clcn6 | Mkrn1 | ENSMUSP00000030879 | ENSMUSP00000031985 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription. | 0.582 |
Clcn6 | Rnf130 | ENSMUSP00000030879 | ENSMUSP00000099837 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | 0.629 |
D630045J12Rik | Clcn6 | ENSMUSP00000130121 | ENSMUSP00000030879 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | 0.493 |
D630045J12Rik | Fam131b | ENSMUSP00000130121 | ENSMUSP00000116779 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | Protein FAM131B. | 0.823 |
D630045J12Rik | Mkrn1 | ENSMUSP00000130121 | ENSMUSP00000031985 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription. | 0.445 |
D630045J12Rik | Rnf130 | ENSMUSP00000130121 | ENSMUSP00000099837 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | 0.543 |
D630045J12Rik | Srgap2 | ENSMUSP00000130121 | ENSMUSP00000095195 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.562 |
D630045J12Rik | Srgap3 | ENSMUSP00000130121 | ENSMUSP00000085712 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity). | 0.617 |
Fam131b | Clcn6 | ENSMUSP00000116779 | ENSMUSP00000030879 | Protein FAM131B. | Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. | 0.727 |
Fam131b | D630045J12Rik | ENSMUSP00000116779 | ENSMUSP00000130121 | Protein FAM131B. | UPF0606 protein KIAA1549; Belongs to the UPF0606 family. | 0.823 |
Fam131b | Fam189a1 | ENSMUSP00000116779 | ENSMUSP00000113680 | Protein FAM131B. | Protein FAM189A1; Belongs to the FAM189 family. | 0.635 |
Fam131b | Mkrn1 | ENSMUSP00000116779 | ENSMUSP00000031985 | Protein FAM131B. | E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription. | 0.647 |
Fam131b | Rnf130 | ENSMUSP00000116779 | ENSMUSP00000099837 | Protein FAM131B. | E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells. | 0.714 |
Fam131b | Srgap2 | ENSMUSP00000116779 | ENSMUSP00000095195 | Protein FAM131B. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.610 |
Fam131b | Srgap3 | ENSMUSP00000116779 | ENSMUSP00000085712 | Protein FAM131B. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity). | 0.670 |
Fam131b | Tmem145 | ENSMUSP00000116779 | ENSMUSP00000104046 | Protein FAM131B. | Transmembrane protein 145. | 0.599 |
Fam131b | Tmem179 | ENSMUSP00000116779 | ENSMUSP00000068004 | Protein FAM131B. | Transmembrane protein 179. | 0.679 |
Fam131b | Tmem88b | ENSMUSP00000116779 | ENSMUSP00000095349 | Protein FAM131B. | Transmembrane protein 88B. | 0.658 |