node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
2210016F16Rik | Fbll1 | ENSMUSP00000022032 | ENSMUSP00000128889 | Queuosine salvage protein; Involved in salvaging queuosine. | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | 0.519 |
2210016F16Rik | Rell1 | ENSMUSP00000022032 | ENSMUSP00000118125 | Queuosine salvage protein; Involved in salvaging queuosine. | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.660 |
Drg1 | Drg2 | ENSMUSP00000020741 | ENSMUSP00000018568 | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.702 |
Drg1 | Gcn1 | ENSMUSP00000020741 | ENSMUSP00000069432 | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | 0.562 |
Drg1 | Rell1 | ENSMUSP00000020741 | ENSMUSP00000118125 | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.675 |
Drg1 | Zc3h15 | ENSMUSP00000020741 | ENSMUSP00000080301 | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity). | 0.998 |
Drg2 | Drg1 | ENSMUSP00000018568 | ENSMUSP00000020741 | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.702 |
Drg2 | Gcn1 | ENSMUSP00000018568 | ENSMUSP00000069432 | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | 0.933 |
Drg2 | Rell1 | ENSMUSP00000018568 | ENSMUSP00000118125 | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.810 |
Drg2 | Zc3h15 | ENSMUSP00000018568 | ENSMUSP00000080301 | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity). | 0.966 |
Fbll1 | 2210016F16Rik | ENSMUSP00000128889 | ENSMUSP00000022032 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | Queuosine salvage protein; Involved in salvaging queuosine. | 0.519 |
Fbll1 | Rell1 | ENSMUSP00000128889 | ENSMUSP00000118125 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.431 |
Gcn1 | Drg1 | ENSMUSP00000069432 | ENSMUSP00000020741 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.562 |
Gcn1 | Drg2 | ENSMUSP00000069432 | ENSMUSP00000018568 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.933 |
Gcn1 | Rell1 | ENSMUSP00000069432 | ENSMUSP00000118125 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.435 |
Gcn1 | Zc3h15 | ENSMUSP00000069432 | ENSMUSP00000080301 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity). | 0.493 |
Map3k4 | Rell1 | ENSMUSP00000086459 | ENSMUSP00000118125 | Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.529 |
Ms4a4d | Rell1 | ENSMUSP00000025581 | ENSMUSP00000118125 | Membrane-spanning 4-domains subfamily A member 4D; May be involved in signal transduction as a component of a multimeric receptor complex. | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | 0.476 |
Rell1 | 2210016F16Rik | ENSMUSP00000118125 | ENSMUSP00000022032 | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | Queuosine salvage protein; Involved in salvaging queuosine. | 0.660 |
Rell1 | Drg1 | ENSMUSP00000118125 | ENSMUSP00000020741 | RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family. | Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] | 0.675 |