STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
1190005I06RikUncharacterized protein C16orf74 homolog. (111 aa)    
Predicted Functional Partners:
Emc1
ER membrane protein complex subunit 1.
    
 
 0.750
Emc2
ER membrane protein complex subunit 2; Belongs to the EMC2 family.
   
 
 0.720
Emc3
ER membrane protein complex subunit 3; Belongs to the EMC3 family.
    
 
 0.653
Emc4
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity.
   
 
 0.645
Ppp3ca
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to t [...]
    
 
 0.575
Emc6
ER membrane protein complex subunit 6; Belongs to the EMC6 family.
   
 
 0.564
Emc7
ER membrane protein complex subunit 7; Belongs to the EMC7 family.
    
 
 0.548
Emc10
ER membrane protein complex subunit 10; Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.
   
 
 0.535
Emc8
ER membrane protein complex subunit 8; Belongs to the EMC8/EMC9 family.
 
 
  
 0.475
Mmgt1
Membrane magnesium transporter 1; Mediates Mg(2+) transport.
    
 
 0.447
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.