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Clcn6 protein (mouse) - STRING interaction network
"Clcn6" - Chloride transport protein 6 in Mus musculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Clcn6Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter (873 aa)    
Predicted Functional Partners:
Cln5
Ceroid-lipofuscinosis neuronal protein 5 homolog; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family (341 aa)
     
   
  0.789
Cln6
Ceroid-lipofuscinosis, neuronal 6 (308 aa)
     
   
  0.781
Sgsh
N-sulfoglucosamine sulfohydrolase (Sulfamidase), isoform CRA_b; N-sulfoglucosamine sulfohydrolase (sulfamidase) (502 aa)
     
   
  0.775
Ostm1
Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (338 aa)
     
 
  0.694
Med19
Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) (244 aa)
           
  0.681
Ocrl
Inositol polyphosphate 5-phosphatase OCRL-1; Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (By similarity); Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family (900 aa)
     
   
  0.679
Fam131b
Protein FAM131B; Family with sequence similarity 131, member B (360 aa)
     
   
  0.678
Prpf3
U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (683 aa)
           
  0.672
Mthfr
Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine (695 aa)
     
   
  0.636
Rnf130
E3 ubiquitin-protein ligase RNF130; Acts as an E3 ubiquitin-protein ligase (By similarity). May have a role during the programmed cell death of hematopoietic cells (419 aa)
           
  0.621
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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