node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Amdhd1 | ENSMUSP00000040853 | ENSMUSP00000016034 | Agmatinase, mitochondrial. | Probable imidazolonepropionase. | 0.436 |
Agmat | Arg1 | ENSMUSP00000040853 | ENSMUSP00000020161 | Agmatinase, mitochondrial. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.535 |
Agmat | Ftcd | ENSMUSP00000040853 | ENSMUSP00000001183 | Agmatinase, mitochondrial. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.427 |
Agmat | Gldc | ENSMUSP00000040853 | ENSMUSP00000025778 | Agmatinase, mitochondrial. | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.539 |
Agmat | Hal | ENSMUSP00000040853 | ENSMUSP00000123336 | Agmatinase, mitochondrial. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.694 |
Amdhd1 | Agmat | ENSMUSP00000016034 | ENSMUSP00000040853 | Probable imidazolonepropionase. | Agmatinase, mitochondrial. | 0.436 |
Amdhd1 | Ftcd | ENSMUSP00000016034 | ENSMUSP00000001183 | Probable imidazolonepropionase. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family. | 0.983 |
Amdhd1 | Hal | ENSMUSP00000016034 | ENSMUSP00000123336 | Probable imidazolonepropionase. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.904 |
Amdhd1 | Uroc1 | ENSMUSP00000016034 | ENSMUSP00000127114 | Probable imidazolonepropionase. | Urocanate hydratase. | 0.990 |
Arg1 | Agmat | ENSMUSP00000020161 | ENSMUSP00000040853 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Agmatinase, mitochondrial. | 0.535 |
Arg1 | Gldc | ENSMUSP00000020161 | ENSMUSP00000025778 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family. | 0.400 |
Arg1 | Hal | ENSMUSP00000020161 | ENSMUSP00000123336 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.758 |
Carns1 | Cndp1 | ENSMUSP00000131624 | ENSMUSP00000069699 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | 0.970 |
Carns1 | Cndp2 | ENSMUSP00000131624 | ENSMUSP00000128696 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis. | 0.958 |
Carns1 | Hal | ENSMUSP00000131624 | ENSMUSP00000123336 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.905 |
Carns1 | Hdc | ENSMUSP00000131624 | ENSMUSP00000028838 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. | 0.916 |
Cndp1 | Carns1 | ENSMUSP00000069699 | ENSMUSP00000131624 | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. | 0.970 |
Cndp1 | Cndp2 | ENSMUSP00000069699 | ENSMUSP00000128696 | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis. | 0.931 |
Cndp1 | Hal | ENSMUSP00000069699 | ENSMUSP00000123336 | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.922 |
Cndp1 | Hdc | ENSMUSP00000069699 | ENSMUSP00000028838 | Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. | 0.919 |