node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cbln2 | Lmo3 | ENSMUSP00000113695 | ENSMUSP00000125335 | Cerebellin-2; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long- term maintenance but not establishment of excitatory synapses. | LIM domain only protein 3. | 0.594 |
Dbx1 | Lmo3 | ENSMUSP00000032717 | ENSMUSP00000125335 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | LIM domain only protein 3. | 0.557 |
Dbx1 | Tal2 | ENSMUSP00000032717 | ENSMUSP00000030124 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | T-cell acute lymphocytic leukemia protein 2 homolog. | 0.509 |
Insm1 | Lmo3 | ENSMUSP00000092048 | ENSMUSP00000125335 | Insulinoma-associated protein 1; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle- independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses ta [...] | LIM domain only protein 3. | 0.502 |
Ldb1 | Lmo3 | ENSMUSP00000118546 | ENSMUSP00000125335 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. | LIM domain only protein 3. | 0.786 |
Ldb1 | Ssbp2 | ENSMUSP00000118546 | ENSMUSP00000004094 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. | Single-stranded DNA-binding protein 2. | 0.978 |
Ldb1 | Tal1 | ENSMUSP00000118546 | ENSMUSP00000030489 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. | T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. | 0.999 |
Ldb1 | Tal2 | ENSMUSP00000118546 | ENSMUSP00000030124 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. | T-cell acute lymphocytic leukemia protein 2 homolog. | 0.653 |
Ldb2 | Lmo3 | ENSMUSP00000067737 | ENSMUSP00000125335 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | LIM domain only protein 3. | 0.786 |
Ldb2 | Ssbp2 | ENSMUSP00000067737 | ENSMUSP00000004094 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Single-stranded DNA-binding protein 2. | 0.890 |
Ldb2 | Tal1 | ENSMUSP00000067737 | ENSMUSP00000030489 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. | 0.683 |
Lmo3 | Cbln2 | ENSMUSP00000125335 | ENSMUSP00000113695 | LIM domain only protein 3. | Cerebellin-2; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long- term maintenance but not establishment of excitatory synapses. | 0.594 |
Lmo3 | Dbx1 | ENSMUSP00000125335 | ENSMUSP00000032717 | LIM domain only protein 3. | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons. | 0.557 |
Lmo3 | Insm1 | ENSMUSP00000125335 | ENSMUSP00000092048 | LIM domain only protein 3. | Insulinoma-associated protein 1; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle- independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses ta [...] | 0.502 |
Lmo3 | Ldb1 | ENSMUSP00000125335 | ENSMUSP00000118546 | LIM domain only protein 3. | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. | 0.786 |
Lmo3 | Ldb2 | ENSMUSP00000125335 | ENSMUSP00000067737 | LIM domain only protein 3. | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | 0.786 |
Lmo3 | Nhlh2 | ENSMUSP00000125335 | ENSMUSP00000143362 | LIM domain only protein 3. | Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | 0.640 |
Lmo3 | Ssbp2 | ENSMUSP00000125335 | ENSMUSP00000004094 | LIM domain only protein 3. | Single-stranded DNA-binding protein 2. | 0.539 |
Lmo3 | Tal1 | ENSMUSP00000125335 | ENSMUSP00000030489 | LIM domain only protein 3. | T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. | 0.477 |
Lmo3 | Tal2 | ENSMUSP00000125335 | ENSMUSP00000030124 | LIM domain only protein 3. | T-cell acute lymphocytic leukemia protein 2 homolog. | 0.490 |