node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dhx35 | Fam83a | ENSMUSP00000029186 | ENSMUSP00000125464 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | 0.513 |
Dhx35 | Ggt7 | ENSMUSP00000029186 | ENSMUSP00000029131 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.634 |
Dhx35 | Rab5if | ENSMUSP00000029186 | ENSMUSP00000029165 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes. | 0.694 |
Dhx35 | Tbc1d31 | ENSMUSP00000029186 | ENSMUSP00000022992 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | TBC1 domain family member 31. | 0.693 |
Dhx35 | Zhx3 | ENSMUSP00000029186 | ENSMUSP00000099400 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA; Belongs to the ZHX family. | 0.589 |
Fam83a | Dhx35 | ENSMUSP00000125464 | ENSMUSP00000029186 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.513 |
Fam83a | Ggt7 | ENSMUSP00000125464 | ENSMUSP00000029131 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.476 |
Fam83a | Kif22 | ENSMUSP00000125464 | ENSMUSP00000032915 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.490 |
Fam83a | Mrpl23 | ENSMUSP00000125464 | ENSMUSP00000039784 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | 39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family. | 0.538 |
Fam83a | Rab5if | ENSMUSP00000125464 | ENSMUSP00000029165 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes. | 0.615 |
Fam83a | Tbc1d31 | ENSMUSP00000125464 | ENSMUSP00000022992 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | TBC1 domain family member 31. | 0.639 |
Fam83a | Trp53i13 | ENSMUSP00000125464 | ENSMUSP00000057592 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity). | 0.524 |
Fam83a | Ttbk2 | ENSMUSP00000125464 | ENSMUSP00000028740 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. | 0.514 |
Fam83a | Zhx3 | ENSMUSP00000125464 | ENSMUSP00000099400 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA; Belongs to the ZHX family. | 0.561 |
Fam83a | Zscan12 | ENSMUSP00000125464 | ENSMUSP00000153548 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation. | 0.554 |
Ggt7 | Dhx35 | ENSMUSP00000029131 | ENSMUSP00000029186 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.634 |
Ggt7 | Fam83a | ENSMUSP00000029131 | ENSMUSP00000125464 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. | 0.476 |
Ggt7 | Rab5if | ENSMUSP00000029131 | ENSMUSP00000029165 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes. | 0.658 |
Ggt7 | Tbc1d31 | ENSMUSP00000029131 | ENSMUSP00000022992 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | TBC1 domain family member 31. | 0.624 |
Ggt7 | Zhx3 | ENSMUSP00000029131 | ENSMUSP00000099400 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA; Belongs to the ZHX family. | 0.555 |