node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aloxe3 | Flg | ENSMUSP00000021268 | ENSMUSP00000142003 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Filaggrin. | 0.458 |
Aloxe3 | Lor | ENSMUSP00000021268 | ENSMUSP00000052128 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Loricrin; Major keratinocyte cell envelope protein. | 0.487 |
Aloxe3 | Nipal4 | ENSMUSP00000021268 | ENSMUSP00000020679 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity); Belongs to the NIPA family. | 0.836 |
Aloxe3 | Pnpla1 | ENSMUSP00000021268 | ENSMUSP00000050123 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase. | 0.757 |
Aloxe3 | Tgm1 | ENSMUSP00000021268 | ENSMUSP00000128090 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.790 |
Cdsn | Evpl | ENSMUSP00000048596 | ENSMUSP00000037850 | Corneodesmosin; Important for the epidermal barrier integrity. | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | 0.692 |
Cdsn | Flg | ENSMUSP00000048596 | ENSMUSP00000142003 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin. | 0.743 |
Cdsn | Ivl | ENSMUSP00000048596 | ENSMUSP00000059780 | Corneodesmosin; Important for the epidermal barrier integrity. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.492 |
Cdsn | Lor | ENSMUSP00000048596 | ENSMUSP00000052128 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.774 |
Cdsn | Ppl | ENSMUSP00000048596 | ENSMUSP00000039360 | Corneodesmosin; Important for the epidermal barrier integrity. | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. | 0.721 |
Cdsn | Rptn | ENSMUSP00000048596 | ENSMUSP00000044998 | Corneodesmosin; Important for the epidermal barrier integrity. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family. | 0.631 |
Cdsn | Tgm1 | ENSMUSP00000048596 | ENSMUSP00000128090 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.812 |
Evpl | Cdsn | ENSMUSP00000037850 | ENSMUSP00000048596 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.692 |
Evpl | Flg | ENSMUSP00000037850 | ENSMUSP00000142003 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Filaggrin. | 0.639 |
Evpl | Ivl | ENSMUSP00000037850 | ENSMUSP00000059780 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.697 |
Evpl | Lor | ENSMUSP00000037850 | ENSMUSP00000052128 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Loricrin; Major keratinocyte cell envelope protein. | 0.727 |
Evpl | Ppl | ENSMUSP00000037850 | ENSMUSP00000039360 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. | 0.994 |
Evpl | Rptn | ENSMUSP00000037850 | ENSMUSP00000044998 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family. | 0.708 |
Evpl | Tgm1 | ENSMUSP00000037850 | ENSMUSP00000128090 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.854 |
Flg | Aloxe3 | ENSMUSP00000142003 | ENSMUSP00000021268 | Filaggrin. | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] | 0.458 |