node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Anxa2 | Coch | ENSMUSP00000034756 | ENSMUSP00000128127 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.495 |
Anxa2 | Kcnk3 | ENSMUSP00000034756 | ENSMUSP00000098987 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | 0.563 |
Bche | Coch | ENSMUSP00000029367 | ENSMUSP00000128127 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.673 |
Coch | Anxa2 | ENSMUSP00000128127 | ENSMUSP00000034756 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.495 |
Coch | Bche | ENSMUSP00000128127 | ENSMUSP00000029367 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family. | 0.673 |
Coch | Fau | ENSMUSP00000128127 | ENSMUSP00000136358 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 0.787 |
Coch | Kcnk2 | ENSMUSP00000128127 | ENSMUSP00000141891 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled recep [...] | 0.677 |
Coch | Kcnk3 | ENSMUSP00000128127 | ENSMUSP00000098987 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | 0.540 |
Coch | Myoc | ENSMUSP00000128127 | ENSMUSP00000028020 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] | 0.451 |
Coch | Slc44a2 | ENSMUSP00000128127 | ENSMUSP00000034697 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Choline transporter-like protein 2; Choline transporter; Belongs to the CTL (choline transporter-like) family. | 0.801 |
Coch | Strc | ENSMUSP00000128127 | ENSMUSP00000039378 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia. | 0.454 |
Coch | Tecta | ENSMUSP00000128127 | ENSMUSP00000040262 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.580 |
Coch | Tectb | ENSMUSP00000128127 | ENSMUSP00000025936 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.629 |
Fau | Coch | ENSMUSP00000136358 | ENSMUSP00000128127 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.787 |
Fau | Tecta | ENSMUSP00000136358 | ENSMUSP00000040262 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. | 0.884 |
Kcnk2 | Coch | ENSMUSP00000141891 | ENSMUSP00000128127 | Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled recep [...] | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.677 |
Kcnk2 | Kcnk3 | ENSMUSP00000141891 | ENSMUSP00000098987 | Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled recep [...] | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | 0.668 |
Kcnk3 | Anxa2 | ENSMUSP00000098987 | ENSMUSP00000034756 | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.563 |
Kcnk3 | Coch | ENSMUSP00000098987 | ENSMUSP00000128127 | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork. | 0.540 |
Kcnk3 | Kcnk2 | ENSMUSP00000098987 | ENSMUSP00000141891 | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. | Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled recep [...] | 0.668 |