node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abtb1 | Mast3 | ENSMUSP00000032169 | ENSMUSP00000148686 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity). | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.481 |
Arpp19 | Mast3 | ENSMUSP00000128921 | ENSMUSP00000148686 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF- regulatory region of its mRNA (By similarity); Belongs to the endosulfine family. | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.418 |
Ensa | Mast3 | ENSMUSP00000051799 | ENSMUSP00000148686 | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.582 |
Glipr1l2 | Mast3 | ENSMUSP00000020434 | ENSMUSP00000148686 | GLIPR1-like protein 2; Belongs to the CRISP family. | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.476 |
Mast2 | Mast3 | ENSMUSP00000102095 | ENSMUSP00000148686 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.472 |
Mast2 | Mast4 | ENSMUSP00000102095 | ENSMUSP00000128464 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | Microtubule-associated serine/threonine-protein kinase 4. | 0.476 |
Mast2 | Nek2 | ENSMUSP00000102095 | ENSMUSP00000027931 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint [...] | 0.465 |
Mast2 | Pten | ENSMUSP00000102095 | ENSMUSP00000013807 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | Phosphatase and tensin homolog; In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of subst [...] | 0.940 |
Mast2 | Sntb2 | ENSMUSP00000102095 | ENSMUSP00000148684 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity); Belongs to the syntrophin family. | 0.848 |
Mast3 | Abtb1 | ENSMUSP00000148686 | ENSMUSP00000032169 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity). | 0.481 |
Mast3 | Arpp19 | ENSMUSP00000148686 | ENSMUSP00000128921 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF- regulatory region of its mRNA (By similarity); Belongs to the endosulfine family. | 0.418 |
Mast3 | Ensa | ENSMUSP00000148686 | ENSMUSP00000051799 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). | 0.582 |
Mast3 | Glipr1l2 | ENSMUSP00000148686 | ENSMUSP00000020434 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | GLIPR1-like protein 2; Belongs to the CRISP family. | 0.476 |
Mast3 | Mast2 | ENSMUSP00000148686 | ENSMUSP00000102095 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | 0.472 |
Mast3 | Mast4 | ENSMUSP00000148686 | ENSMUSP00000128464 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Microtubule-associated serine/threonine-protein kinase 4. | 0.609 |
Mast3 | Nek2 | ENSMUSP00000148686 | ENSMUSP00000027931 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint [...] | 0.463 |
Mast3 | Pten | ENSMUSP00000148686 | ENSMUSP00000013807 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Phosphatase and tensin homolog; In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of subst [...] | 0.434 |
Mast3 | Sntb2 | ENSMUSP00000148686 | ENSMUSP00000148684 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity); Belongs to the syntrophin family. | 0.668 |
Mast3 | Wdr88 | ENSMUSP00000148686 | ENSMUSP00000158765 | Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | WD_REPEATS_REGION domain-containing protein. | 0.466 |
Mast4 | Mast2 | ENSMUSP00000128464 | ENSMUSP00000102095 | Microtubule-associated serine/threonine-protein kinase 4. | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. | 0.476 |