node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc69 | Tbck | ENSMUSP00000054840 | ENSMUSP00000129205 | Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.455 |
Cln3 | Cln5 | ENSMUSP00000081636 | ENSMUSP00000022721 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.974 |
Cln3 | Mfsd8 | ENSMUSP00000081636 | ENSMUSP00000026859 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | 0.881 |
Cln3 | Tbck | ENSMUSP00000081636 | ENSMUSP00000129205 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.470 |
Cln5 | Cln3 | ENSMUSP00000022721 | ENSMUSP00000081636 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.974 |
Cln5 | Mfsd8 | ENSMUSP00000022721 | ENSMUSP00000026859 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | 0.881 |
Cln5 | Tbck | ENSMUSP00000022721 | ENSMUSP00000129205 | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.456 |
Cnpy2 | Nme6 | ENSMUSP00000151918 | ENSMUSP00000035053 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.509 |
Cnpy2 | Tbck | ENSMUSP00000151918 | ENSMUSP00000129205 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.507 |
Cnpy2 | Wdr47 | ENSMUSP00000151918 | ENSMUSP00000057482 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | WD repeat-containing protein 47. | 0.453 |
D6Wsu163e | Ppp1r21 | ENSMUSP00000032497 | ENSMUSP00000048443 | Protein C12orf4 homolog; Plays a role in mast cell degranulation. | Protein phosphatase 1 regulatory subunit 21; utative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | 0.843 |
D6Wsu163e | Tbck | ENSMUSP00000032497 | ENSMUSP00000129205 | Protein C12orf4 homolog; Plays a role in mast cell degranulation. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.776 |
Mfsd8 | Cln3 | ENSMUSP00000026859 | ENSMUSP00000081636 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.881 |
Mfsd8 | Cln5 | ENSMUSP00000026859 | ENSMUSP00000022721 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.881 |
Mfsd8 | Tbck | ENSMUSP00000026859 | ENSMUSP00000129205 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.455 |
Mob1a | Tbck | ENSMUSP00000054452 | ENSMUSP00000129205 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.463 |
Nme6 | Cnpy2 | ENSMUSP00000035053 | ENSMUSP00000151918 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family. | 0.509 |
Nme6 | Tbck | ENSMUSP00000035053 | ENSMUSP00000129205 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization; Belongs to the protein kinase superfamily. | 0.556 |
Nme6 | Wdr47 | ENSMUSP00000035053 | ENSMUSP00000057482 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | WD repeat-containing protein 47. | 0.475 |
Ppp1r21 | D6Wsu163e | ENSMUSP00000048443 | ENSMUSP00000032497 | Protein phosphatase 1 regulatory subunit 21; utative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway. | Protein C12orf4 homolog; Plays a role in mast cell degranulation. | 0.843 |