node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acot4 | Heatr4 | ENSMUSP00000021652 | ENSMUSP00000129832 | Peroxisomal succinyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. In contrast to human peroxisomal succinyl-coenzyme A thioesterase/ACOT4, mouse ACOT4 is essentially a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl- CoAs and with a low activity toward glutaryl-CoA. Belongs to the C/M/P thioester hydrolase family. | HEAT repeat-containing 4. | 0.470 |
Dnaaf5 | Heatr4 | ENSMUSP00000026975 | ENSMUSP00000129832 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | HEAT repeat-containing 4. | 0.487 |
Dnaaf5 | Heatr6 | ENSMUSP00000026975 | ENSMUSP00000001002 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | HEAT repeat-containing protein 6. | 0.435 |
Dnaaf5 | Ints4 | ENSMUSP00000026975 | ENSMUSP00000026126 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.436 |
Dnaaf5 | Rsph14 | ENSMUSP00000026975 | ENSMUSP00000131632 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family. | 0.471 |
Heatr4 | Acot4 | ENSMUSP00000129832 | ENSMUSP00000021652 | HEAT repeat-containing 4. | Peroxisomal succinyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. In contrast to human peroxisomal succinyl-coenzyme A thioesterase/ACOT4, mouse ACOT4 is essentially a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl- CoAs and with a low activity toward glutaryl-CoA. Belongs to the C/M/P thioester hydrolase family. | 0.470 |
Heatr4 | Dnaaf5 | ENSMUSP00000129832 | ENSMUSP00000026975 | HEAT repeat-containing 4. | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | 0.487 |
Heatr4 | Heatr6 | ENSMUSP00000129832 | ENSMUSP00000001002 | HEAT repeat-containing 4. | HEAT repeat-containing protein 6. | 0.673 |
Heatr4 | Ints4 | ENSMUSP00000129832 | ENSMUSP00000026126 | HEAT repeat-containing 4. | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.603 |
Heatr4 | Lrrc55 | ENSMUSP00000129832 | ENSMUSP00000107228 | HEAT repeat-containing 4. | Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). | 0.489 |
Heatr4 | Lrrc61 | ENSMUSP00000129832 | ENSMUSP00000110192 | HEAT repeat-containing 4. | Leucine-rich repeat-containing protein 61. | 0.651 |
Heatr4 | Relch | ENSMUSP00000129832 | ENSMUSP00000039178 | HEAT repeat-containing 4. | RAB11-binding protein RELCH; Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP- mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes. | 0.550 |
Heatr4 | Rsph14 | ENSMUSP00000129832 | ENSMUSP00000131632 | HEAT repeat-containing 4. | Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family. | 0.680 |
Heatr4 | Stk36 | ENSMUSP00000129832 | ENSMUSP00000084430 | HEAT repeat-containing 4. | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.544 |
Heatr4 | Tango6 | ENSMUSP00000129832 | ENSMUSP00000043953 | HEAT repeat-containing 4. | Transport and Golgi organization protein 6 homolog; Belongs to the Tango6 family. | 0.604 |
Heatr6 | Dnaaf5 | ENSMUSP00000001002 | ENSMUSP00000026975 | HEAT repeat-containing protein 6. | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. | 0.435 |
Heatr6 | Heatr4 | ENSMUSP00000001002 | ENSMUSP00000129832 | HEAT repeat-containing protein 6. | HEAT repeat-containing 4. | 0.673 |
Heatr6 | Ints4 | ENSMUSP00000001002 | ENSMUSP00000026126 | HEAT repeat-containing protein 6. | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.653 |
Heatr6 | Relch | ENSMUSP00000001002 | ENSMUSP00000039178 | HEAT repeat-containing protein 6. | RAB11-binding protein RELCH; Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP- mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes. | 0.665 |
Heatr6 | Rsph14 | ENSMUSP00000001002 | ENSMUSP00000131632 | HEAT repeat-containing protein 6. | Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family. | 0.490 |