STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CalyNeuron-specific vesicular protein calcyon; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. (226 aa)    
Predicted Functional Partners:
Drd1
D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
   
 
 0.940
Ngrn
Neugrin; Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system; Belongs to the neugrin family.
      
 0.511
Rundc3a
RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family.
   
  
 0.480
Hpcal4
Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family.
   
  
 0.457
Tssk4
Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
      
 0.447
Samd5
Sterile alpha motif domain-containing protein 5.
      
 0.446
Sh3bgrl2
SH3 domain-binding glutamic acid-rich-like protein 2.
      
 0.435
Tmem59l
Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). Belongs to the TMEM59 family.
   
  
 0.422
Cdk5r2
Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII; Belongs to the cyclin-dependent kinase 5 activator family.
   
  
 0.421
Cend1
Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation. Belongs to the CEND1 family.
   
  
 0.416
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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