STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CalyNeuron-specific vesicular protein calcyon; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis (226 aa)    
Predicted Functional Partners:
Drd1a
D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase
   
 0.869
Hpcal4
Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation
   
  
 0.597
Sez6l
Seizure related 6 homolog like; Seizure 6-like protein; Candidate tumor suppressor gene. May contribute to specialized endoplasmic reticulum functions in neurons
   
  
 0.561
Ngrn
Neugrin, neurite outgrowth associated; Neugrin; May be involved in neuronal differentiation; Belongs to the neugrin family
   
  
 0.536
Samd5
Sterile alpha motif domain-containing protein 5; Sterile alpha motif domain containing 5
   
  
 0.525
Tmem130
Transmembrane protein 130
   
  
 0.521
Rundc3a
RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells; Belongs to the RUNDC3 family
   
  
 0.513
Rp9
Retinitis pigmentosa 9 protein homolog; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1
      
 0.513
Resp18
Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs; Belongs to the RESP18 family
   
  
 0.510
Zfp64
Zinc finger protein 64, isoform cra_b; May be involved in transcriptional regulation
      
 0.501
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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