node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btla | Cd5 | ENSMUSP00000067877 | ENSMUSP00000025571 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.781 |
Btla | Cd6 | ENSMUSP00000067877 | ENSMUSP00000079172 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | 0.589 |
Btla | Grb2 | ENSMUSP00000067877 | ENSMUSP00000021090 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.831 |
Btla | Lax1 | ENSMUSP00000067877 | ENSMUSP00000131126 | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. | 0.592 |
Cd5 | Btla | ENSMUSP00000025571 | ENSMUSP00000067877 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | 0.781 |
Cd5 | Cd6 | ENSMUSP00000025571 | ENSMUSP00000079172 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | 0.885 |
Cd5 | Grb2 | ENSMUSP00000025571 | ENSMUSP00000021090 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.672 |
Cd5 | Lat | ENSMUSP00000025571 | ENSMUSP00000032997 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] | 0.570 |
Cd5 | Lax1 | ENSMUSP00000025571 | ENSMUSP00000131126 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. | 0.609 |
Cd5 | Trat1 | ENSMUSP00000025571 | ENSMUSP00000155986 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.521 |
Cd6 | Btla | ENSMUSP00000079172 | ENSMUSP00000067877 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. | 0.589 |
Cd6 | Cd5 | ENSMUSP00000079172 | ENSMUSP00000025571 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. | 0.885 |
Cd6 | Grap2 | ENSMUSP00000079172 | ENSMUSP00000046532 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family. | 0.455 |
Cd6 | Lat | ENSMUSP00000079172 | ENSMUSP00000032997 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] | 0.666 |
Cd6 | Lax1 | ENSMUSP00000079172 | ENSMUSP00000131126 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. | 0.637 |
Cd6 | Trat1 | ENSMUSP00000079172 | ENSMUSP00000155986 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.840 |
Grap2 | Cd6 | ENSMUSP00000046532 | ENSMUSP00000079172 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family. | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] | 0.455 |
Grap2 | Grb2 | ENSMUSP00000046532 | ENSMUSP00000021090 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.991 |
Grap2 | Lat | ENSMUSP00000046532 | ENSMUSP00000032997 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family. | Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] | 0.997 |
Grap2 | Lat2 | ENSMUSP00000046532 | ENSMUSP00000046900 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family. | Linker for activation of T-cells family member 2; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. | 0.760 |