node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Isoc2a | Izumo2 | ENSMUSP00000131514 | ENSMUSP00000082543 | Isochorismatase domain-containing protein 2A. | Izumo sperm-egg fusion protein 2. | 0.709 |
Isoc2a | Izumo3 | ENSMUSP00000131514 | ENSMUSP00000102725 | Isochorismatase domain-containing protein 2A. | Izumo sperm-egg fusion protein 3. | 0.448 |
Isoc2a | Myl9 | ENSMUSP00000131514 | ENSMUSP00000085913 | Isochorismatase domain-containing protein 2A. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.575 |
Isoc2a | Nit2 | ENSMUSP00000131514 | ENSMUSP00000023432 | Isochorismatase domain-containing protein 2A. | Omega-amidase NIT2; Possesses omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. Can hydrolyze glutaramate, succinate and gamma- monomethyl-alpha-ketoglutarate in vitro. | 0.562 |
Isoc2a | Nsun5 | ENSMUSP00000131514 | ENSMUSP00000000940 | Isochorismatase domain-containing protein 2A. | Probable 28S rRNA (cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.507 |
Isoc2a | Pi4ka | ENSMUSP00000131514 | ENSMUSP00000156049 | Isochorismatase domain-containing protein 2A. | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.608 |
Isoc2a | Qprt | ENSMUSP00000131514 | ENSMUSP00000032912 | Isochorismatase domain-containing protein 2A. | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.452 |
Isoc2a | Rack1 | ENSMUSP00000131514 | ENSMUSP00000020640 | Isochorismatase domain-containing protein 2A. | Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] | 0.486 |
Isoc2a | Rasip1 | ENSMUSP00000131514 | ENSMUSP00000062429 | Isochorismatase domain-containing protein 2A. | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated trans [...] | 0.571 |
Isoc2a | Timm21 | ENSMUSP00000131514 | ENSMUSP00000025547 | Isochorismatase domain-containing protein 2A. | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Be [...] | 0.518 |
Izumo2 | Isoc2a | ENSMUSP00000082543 | ENSMUSP00000131514 | Izumo sperm-egg fusion protein 2. | Isochorismatase domain-containing protein 2A. | 0.709 |
Izumo2 | Izumo3 | ENSMUSP00000082543 | ENSMUSP00000102725 | Izumo sperm-egg fusion protein 2. | Izumo sperm-egg fusion protein 3. | 0.907 |
Izumo2 | Rasip1 | ENSMUSP00000082543 | ENSMUSP00000062429 | Izumo sperm-egg fusion protein 2. | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated trans [...] | 0.596 |
Izumo3 | Isoc2a | ENSMUSP00000102725 | ENSMUSP00000131514 | Izumo sperm-egg fusion protein 3. | Isochorismatase domain-containing protein 2A. | 0.448 |
Izumo3 | Izumo2 | ENSMUSP00000102725 | ENSMUSP00000082543 | Izumo sperm-egg fusion protein 3. | Izumo sperm-egg fusion protein 2. | 0.907 |
Myl9 | Isoc2a | ENSMUSP00000085913 | ENSMUSP00000131514 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | Isochorismatase domain-containing protein 2A. | 0.575 |
Myl9 | Timm21 | ENSMUSP00000085913 | ENSMUSP00000025547 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Be [...] | 0.424 |
Nit2 | Isoc2a | ENSMUSP00000023432 | ENSMUSP00000131514 | Omega-amidase NIT2; Possesses omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. Can hydrolyze glutaramate, succinate and gamma- monomethyl-alpha-ketoglutarate in vitro. | Isochorismatase domain-containing protein 2A. | 0.562 |
Nsun5 | Isoc2a | ENSMUSP00000000940 | ENSMUSP00000131514 | Probable 28S rRNA (cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Isochorismatase domain-containing protein 2A. | 0.507 |
Pi4ka | Isoc2a | ENSMUSP00000156049 | ENSMUSP00000131514 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | Isochorismatase domain-containing protein 2A. | 0.608 |