node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aipl1 | Cluap1 | ENSMUSP00000036279 | ENSMUSP00000043397 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | 0.416 |
Aipl1 | Dthd1 | ENSMUSP00000036279 | ENSMUSP00000131534 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | Death domain-containing 1. | 0.521 |
Aipl1 | Rd3 | ENSMUSP00000036279 | ENSMUSP00000138049 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | Protein RD3; Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP- stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in t [...] | 0.739 |
Aipl1 | Spata7 | ENSMUSP00000036279 | ENSMUSP00000045827 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | Spermatogenesis-associated protein 7 homolog; Involved in the maintenance of both rod and cone photoreceptor cells. Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone. Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration. | 0.794 |
Aipl1 | Tulp1 | ENSMUSP00000036279 | ENSMUSP00000049070 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4- bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similari [...] | 0.774 |
Cfap161 | Dthd1 | ENSMUSP00000011298 | ENSMUSP00000131534 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Death domain-containing 1. | 0.467 |
Cfap161 | Morn5 | ENSMUSP00000011298 | ENSMUSP00000028256 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | MORN repeat-containing protein 5. | 0.740 |
Cluap1 | Aipl1 | ENSMUSP00000043397 | ENSMUSP00000036279 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | 0.416 |
Cluap1 | Dthd1 | ENSMUSP00000043397 | ENSMUSP00000131534 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | Death domain-containing 1. | 0.555 |
Cluap1 | Ift140 | ENSMUSP00000043397 | ENSMUSP00000024983 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells. | 0.964 |
Cluap1 | Rd3 | ENSMUSP00000043397 | ENSMUSP00000138049 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | Protein RD3; Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP- stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in t [...] | 0.429 |
Cluap1 | Spata7 | ENSMUSP00000043397 | ENSMUSP00000045827 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | Spermatogenesis-associated protein 7 homolog; Involved in the maintenance of both rod and cone photoreceptor cells. Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone. Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration. | 0.531 |
Dthd1 | Aipl1 | ENSMUSP00000131534 | ENSMUSP00000036279 | Death domain-containing 1. | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization. | 0.521 |
Dthd1 | Cfap161 | ENSMUSP00000131534 | ENSMUSP00000011298 | Death domain-containing 1. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.467 |
Dthd1 | Cluap1 | ENSMUSP00000131534 | ENSMUSP00000043397 | Death domain-containing 1. | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. | 0.555 |
Dthd1 | Ift140 | ENSMUSP00000131534 | ENSMUSP00000024983 | Death domain-containing 1. | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells. | 0.460 |
Dthd1 | Lmntd1 | ENSMUSP00000131534 | ENSMUSP00000107337 | Death domain-containing 1. | Lamin tail domain-containing protein 1; Belongs to the intermediate filament family. | 0.466 |
Dthd1 | Lrrc74b | ENSMUSP00000131534 | ENSMUSP00000097699 | Death domain-containing 1. | Leucine-rich repeat-containing protein 74B. | 0.463 |
Dthd1 | Morn5 | ENSMUSP00000131534 | ENSMUSP00000028256 | Death domain-containing 1. | MORN repeat-containing protein 5. | 0.519 |
Dthd1 | Rd3 | ENSMUSP00000131534 | ENSMUSP00000138049 | Death domain-containing 1. | Protein RD3; Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP- stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in t [...] | 0.516 |