node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acan | Adamts3 | ENSMUSP00000032835 | ENSMUSP00000132219 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | 0.604 |
Acan | Col11a1 | ENSMUSP00000032835 | ENSMUSP00000089793 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Belongs to the fibrillar collagen family. | 0.630 |
Acan | Col2a1 | ENSMUSP00000032835 | ENSMUSP00000023123 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.942 |
Acan | Mmp13 | ENSMUSP00000032835 | ENSMUSP00000015394 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.910 |
Adamts3 | Acan | ENSMUSP00000132219 | ENSMUSP00000032835 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.604 |
Adamts3 | Asna1 | ENSMUSP00000132219 | ENSMUSP00000065337 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.535 |
Adamts3 | Ccbe1 | ENSMUSP00000132219 | ENSMUSP00000117636 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 family. | 0.854 |
Adamts3 | Col11a1 | ENSMUSP00000132219 | ENSMUSP00000089793 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Belongs to the fibrillar collagen family. | 0.505 |
Adamts3 | Col2a1 | ENSMUSP00000132219 | ENSMUSP00000023123 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | 0.574 |
Adamts3 | Cx3cl1 | ENSMUSP00000132219 | ENSMUSP00000034230 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Processed fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophil [...] | 0.518 |
Adamts3 | Fat4 | ENSMUSP00000132219 | ENSMUSP00000061836 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Protocadherin Fat 4; Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. | 0.527 |
Adamts3 | Mmp13 | ENSMUSP00000132219 | ENSMUSP00000015394 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] | 0.545 |
Adamts3 | Tmem86a | ENSMUSP00000132219 | ENSMUSP00000010451 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Lysoplasmalogenase-like protein TMEM86A. | 0.510 |
Adamts3 | Vegfc | ENSMUSP00000132219 | ENSMUSP00000033919 | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | Vascular endothelial growth factor C; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. | 0.601 |
Asna1 | Adamts3 | ENSMUSP00000065337 | ENSMUSP00000132219 | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | 0.535 |
Asna1 | Cx3cl1 | ENSMUSP00000065337 | ENSMUSP00000034230 | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Processed fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophil [...] | 0.470 |
Asna1 | Tmem86a | ENSMUSP00000065337 | ENSMUSP00000010451 | ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Lysoplasmalogenase-like protein TMEM86A. | 0.620 |
Ccbe1 | Adamts3 | ENSMUSP00000117636 | ENSMUSP00000132219 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 family. | A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3. | 0.854 |
Ccbe1 | Fat4 | ENSMUSP00000117636 | ENSMUSP00000061836 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 family. | Protocadherin Fat 4; Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. | 0.518 |
Ccbe1 | Vegfc | ENSMUSP00000117636 | ENSMUSP00000033919 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 family. | Vascular endothelial growth factor C; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. | 0.831 |