node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cab39l | Loxhd1 | ENSMUSP00000022553 | ENSMUSP00000094294 | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). | Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear. | 0.453 |
Cab39l | Myo3a | ENSMUSP00000022553 | ENSMUSP00000046329 | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the [...] | 0.413 |
Cab39l | Skor2 | ENSMUSP00000022553 | ENSMUSP00000132338 | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.519 |
En1 | Ptf1a | ENSMUSP00000078659 | ENSMUSP00000028068 | Homeobox protein engrailed-1. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.447 |
En1 | Skor2 | ENSMUSP00000078659 | ENSMUSP00000132338 | Homeobox protein engrailed-1. | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.476 |
Hdac1 | Skor2 | ENSMUSP00000099657 | ENSMUSP00000132338 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.476 |
Kirrel2 | Ptf1a | ENSMUSP00000039395 | ENSMUSP00000028068 | Kin of IRRE-like protein 2; May regulate basal insulin secretion. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.553 |
Kirrel2 | Skor2 | ENSMUSP00000039395 | ENSMUSP00000132338 | Kin of IRRE-like protein 2; May regulate basal insulin secretion. | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.612 |
Lhx5 | Ptf1a | ENSMUSP00000031591 | ENSMUSP00000028068 | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | 0.535 |
Lhx5 | Skor2 | ENSMUSP00000031591 | ENSMUSP00000132338 | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.485 |
Loxhd1 | Cab39l | ENSMUSP00000094294 | ENSMUSP00000022553 | Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear. | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). | 0.453 |
Loxhd1 | Myo3a | ENSMUSP00000094294 | ENSMUSP00000046329 | Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear. | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the [...] | 0.802 |
Loxhd1 | Skor2 | ENSMUSP00000094294 | ENSMUSP00000132338 | Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear. | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.656 |
Myo3a | Cab39l | ENSMUSP00000046329 | ENSMUSP00000022553 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the [...] | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity). | 0.413 |
Myo3a | Loxhd1 | ENSMUSP00000046329 | ENSMUSP00000094294 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the [...] | Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear. | 0.802 |
Myo3a | Skor2 | ENSMUSP00000046329 | ENSMUSP00000132338 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the [...] | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.511 |
Ptf1a | En1 | ENSMUSP00000028068 | ENSMUSP00000078659 | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | Homeobox protein engrailed-1. | 0.447 |
Ptf1a | Kirrel2 | ENSMUSP00000028068 | ENSMUSP00000039395 | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | Kin of IRRE-like protein 2; May regulate basal insulin secretion. | 0.553 |
Ptf1a | Lhx5 | ENSMUSP00000028068 | ENSMUSP00000031591 | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. | 0.535 |
Ptf1a | Skor2 | ENSMUSP00000028068 | ENSMUSP00000132338 | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] | SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. | 0.512 |