node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acsl4 | Cars | ENSMUSP00000033634 | ENSMUSP00000010899 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Cysteine--tRNA ligase, cytoplasmic. | 0.489 |
Acsl4 | Cars2 | ENSMUSP00000033634 | ENSMUSP00000046453 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Probable cysteine--tRNA ligase, mitochondrial. | 0.440 |
Acsl4 | Hsbp1l1 | ENSMUSP00000033634 | ENSMUSP00000132852 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | 0.461 |
Acsl4 | Ireb2 | ENSMUSP00000033634 | ENSMUSP00000034843 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.633 |
Acsl4 | Lpcat3 | ENSMUSP00000033634 | ENSMUSP00000004381 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidyl [...] | 0.856 |
Acsl4 | Nfs1 | ENSMUSP00000033634 | ENSMUSP00000029147 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity); Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.411 |
Cars | Acsl4 | ENSMUSP00000010899 | ENSMUSP00000033634 | Cysteine--tRNA ligase, cytoplasmic. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | 0.489 |
Cars | Cars2 | ENSMUSP00000010899 | ENSMUSP00000046453 | Cysteine--tRNA ligase, cytoplasmic. | Probable cysteine--tRNA ligase, mitochondrial. | 0.912 |
Cars | Hsbp1l1 | ENSMUSP00000010899 | ENSMUSP00000132852 | Cysteine--tRNA ligase, cytoplasmic. | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | 0.489 |
Cars | Ireb2 | ENSMUSP00000010899 | ENSMUSP00000034843 | Cysteine--tRNA ligase, cytoplasmic. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.497 |
Cars | Lpcat3 | ENSMUSP00000010899 | ENSMUSP00000004381 | Cysteine--tRNA ligase, cytoplasmic. | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidyl [...] | 0.506 |
Cars2 | Acsl4 | ENSMUSP00000046453 | ENSMUSP00000033634 | Probable cysteine--tRNA ligase, mitochondrial. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | 0.440 |
Cars2 | Cars | ENSMUSP00000046453 | ENSMUSP00000010899 | Probable cysteine--tRNA ligase, mitochondrial. | Cysteine--tRNA ligase, cytoplasmic. | 0.912 |
Cars2 | Hsbp1l1 | ENSMUSP00000046453 | ENSMUSP00000132852 | Probable cysteine--tRNA ligase, mitochondrial. | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | 0.477 |
Cars2 | Ireb2 | ENSMUSP00000046453 | ENSMUSP00000034843 | Probable cysteine--tRNA ligase, mitochondrial. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.472 |
Cars2 | Lpcat3 | ENSMUSP00000046453 | ENSMUSP00000004381 | Probable cysteine--tRNA ligase, mitochondrial. | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidyl [...] | 0.473 |
Fam227a | Hsbp1l1 | ENSMUSP00000139524 | ENSMUSP00000132852 | Family with sequence similarity 227, member A. | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | 0.580 |
Hsbp1l1 | Acsl4 | ENSMUSP00000132852 | ENSMUSP00000033634 | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | 0.461 |
Hsbp1l1 | Cars | ENSMUSP00000132852 | ENSMUSP00000010899 | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | Cysteine--tRNA ligase, cytoplasmic. | 0.489 |
Hsbp1l1 | Cars2 | ENSMUSP00000132852 | ENSMUSP00000046453 | Heat shock factor-binding protein 1-like protein 1; Belongs to the HSBP1 family. | Probable cysteine--tRNA ligase, mitochondrial. | 0.477 |