node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bco2 | Kbtbd12 | ENSMUSP00000112727 | ENSMUSP00000112581 | Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta- ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family. | Kelch repeat and BTB domain-containing protein 12. | 0.594 |
Ccdc36 | Kbtbd12 | ENSMUSP00000075898 | ENSMUSP00000112581 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Kelch repeat and BTB domain-containing protein 12. | 0.642 |
Ccdc36 | Kcng3 | ENSMUSP00000075898 | ENSMUSP00000054910 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Potassium voltage-gated channel subfamily G member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. | 0.558 |
Ccdc36 | Rrp36 | ENSMUSP00000075898 | ENSMUSP00000024766 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family. | 0.634 |
Ccdc36 | Sipa1l2 | ENSMUSP00000075898 | ENSMUSP00000148536 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Signal-induced proliferation-associated 1-like protein 2. | 0.554 |
Ccdc36 | Togaram1 | ENSMUSP00000075898 | ENSMUSP00000070382 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4. Belongs to the Crescerin family. | 0.526 |
Ccdc36 | Trappc6b | ENSMUSP00000075898 | ENSMUSP00000021380 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). Belongs to the TRAPP small subunits family. BET3 subfamily. | 0.516 |
Immp2l | Kbtbd12 | ENSMUSP00000118779 | ENSMUSP00000112581 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). | Kelch repeat and BTB domain-containing protein 12. | 0.622 |
Immp2l | Tmem117 | ENSMUSP00000118779 | ENSMUSP00000079038 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family. | 0.469 |
Immp2l | Tmem161b | ENSMUSP00000118779 | ENSMUSP00000055208 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). | Transmembrane protein 161B. | 0.581 |
Kbtbd12 | Bco2 | ENSMUSP00000112581 | ENSMUSP00000112727 | Kelch repeat and BTB domain-containing protein 12. | Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta- ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family. | 0.594 |
Kbtbd12 | Ccdc36 | ENSMUSP00000112581 | ENSMUSP00000075898 | Kelch repeat and BTB domain-containing protein 12. | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | 0.642 |
Kbtbd12 | Immp2l | ENSMUSP00000112581 | ENSMUSP00000118779 | Kelch repeat and BTB domain-containing protein 12. | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity). | 0.622 |
Kbtbd12 | Kcng3 | ENSMUSP00000112581 | ENSMUSP00000054910 | Kelch repeat and BTB domain-containing protein 12. | Potassium voltage-gated channel subfamily G member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. | 0.659 |
Kbtbd12 | Rrp36 | ENSMUSP00000112581 | ENSMUSP00000024766 | Kelch repeat and BTB domain-containing protein 12. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family. | 0.672 |
Kbtbd12 | Sipa1l2 | ENSMUSP00000112581 | ENSMUSP00000148536 | Kelch repeat and BTB domain-containing protein 12. | Signal-induced proliferation-associated 1-like protein 2. | 0.592 |
Kbtbd12 | Tmem117 | ENSMUSP00000112581 | ENSMUSP00000079038 | Kelch repeat and BTB domain-containing protein 12. | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family. | 0.576 |
Kbtbd12 | Tmem161b | ENSMUSP00000112581 | ENSMUSP00000055208 | Kelch repeat and BTB domain-containing protein 12. | Transmembrane protein 161B. | 0.739 |
Kbtbd12 | Togaram1 | ENSMUSP00000112581 | ENSMUSP00000070382 | Kelch repeat and BTB domain-containing protein 12. | TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4. Belongs to the Crescerin family. | 0.641 |
Kbtbd12 | Trappc6b | ENSMUSP00000112581 | ENSMUSP00000021380 | Kelch repeat and BTB domain-containing protein 12. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). Belongs to the TRAPP small subunits family. BET3 subfamily. | 0.608 |