node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdh23 | Cdhr3 | ENSMUSP00000101104 | ENSMUSP00000093449 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. | 0.420 |
Cdh23 | Cdhr4 | ENSMUSP00000101104 | ENSMUSP00000135184 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | Cadherin-related family member 4. | 0.469 |
Cdhr3 | Cdh23 | ENSMUSP00000093449 | ENSMUSP00000101104 | Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | 0.420 |
Cdhr3 | Cdhr4 | ENSMUSP00000093449 | ENSMUSP00000135184 | Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. | Cadherin-related family member 4. | 0.443 |
Cdhr4 | Cdh23 | ENSMUSP00000135184 | ENSMUSP00000101104 | Cadherin-related family member 4. | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. | 0.469 |
Cdhr4 | Cdhr3 | ENSMUSP00000135184 | ENSMUSP00000093449 | Cadherin-related family member 4. | Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. | 0.443 |
Cdhr4 | Cnfn | ENSMUSP00000135184 | ENSMUSP00000130957 | Cadherin-related family member 4. | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | 0.423 |
Cdhr4 | Ip6k1 | ENSMUSP00000135184 | ENSMUSP00000035214 | Cadherin-related family member 4. | Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. | 0.512 |
Cdhr4 | Klhl3 | ENSMUSP00000135184 | ENSMUSP00000123701 | Cadherin-related family member 4. | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney. | 0.400 |
Cdhr4 | Mon1a | ENSMUSP00000135184 | ENSMUSP00000035202 | Cadherin-related family member 4. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity). | 0.500 |
Cdhr4 | Mst1r | ENSMUSP00000135184 | ENSMUSP00000035203 | Cadherin-related family member 4. | Macrophage-stimulating protein receptor alpha chain; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON lea [...] | 0.405 |
Cdhr4 | R3hdm1 | ENSMUSP00000135184 | ENSMUSP00000043103 | Cadherin-related family member 4. | R3H domain-containing 1. | 0.437 |
Cdhr4 | Rnf123 | ENSMUSP00000135184 | ENSMUSP00000125745 | Cadherin-related family member 4. | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. | 0.469 |
Cdhr4 | Xkr4 | ENSMUSP00000135184 | ENSMUSP00000070648 | Cadherin-related family member 4. | XK-related protein 4. | 0.432 |
Cnfn | Cdhr4 | ENSMUSP00000130957 | ENSMUSP00000135184 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. | Cadherin-related family member 4. | 0.423 |
Ip6k1 | Cdhr4 | ENSMUSP00000035214 | ENSMUSP00000135184 | Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. | Cadherin-related family member 4. | 0.512 |
Ip6k1 | Rnf123 | ENSMUSP00000035214 | ENSMUSP00000125745 | Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. | 0.501 |
Klhl3 | Cdhr4 | ENSMUSP00000123701 | ENSMUSP00000135184 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney. | Cadherin-related family member 4. | 0.400 |
Mon1a | Cdhr4 | ENSMUSP00000035202 | ENSMUSP00000135184 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity). | Cadherin-related family member 4. | 0.500 |
Mon1a | Rnf123 | ENSMUSP00000035202 | ENSMUSP00000125745 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity). | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS. | 0.456 |