node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl6ip6 | Fam177a2 | ENSMUSP00000028336 | ENSMUSP00000137377 | ADP-ribosylation factor-like protein 6-interacting protein 6. | Family with sequence similarity 177 member A2. | 0.473 |
Arl6ip6 | Med29 | ENSMUSP00000028336 | ENSMUSP00000003536 | ADP-ribosylation factor-like protein 6-interacting protein 6. | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.644 |
Cpsf1 | Fam177a2 | ENSMUSP00000071794 | ENSMUSP00000137377 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | Family with sequence similarity 177 member A2. | 0.431 |
Depdc7 | Fam177a2 | ENSMUSP00000028595 | ENSMUSP00000137377 | DEP domain-containing protein 7. | Family with sequence similarity 177 member A2. | 0.592 |
Fam135b | Fam177a2 | ENSMUSP00000022953 | ENSMUSP00000137377 | Protein FAM135B; Belongs to the FAM135 family. | Family with sequence similarity 177 member A2. | 0.498 |
Fam177a2 | Arl6ip6 | ENSMUSP00000137377 | ENSMUSP00000028336 | Family with sequence similarity 177 member A2. | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.473 |
Fam177a2 | Cpsf1 | ENSMUSP00000137377 | ENSMUSP00000071794 | Family with sequence similarity 177 member A2. | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | 0.431 |
Fam177a2 | Depdc7 | ENSMUSP00000137377 | ENSMUSP00000028595 | Family with sequence similarity 177 member A2. | DEP domain-containing protein 7. | 0.592 |
Fam177a2 | Fam135b | ENSMUSP00000137377 | ENSMUSP00000022953 | Family with sequence similarity 177 member A2. | Protein FAM135B; Belongs to the FAM135 family. | 0.498 |
Fam177a2 | Lipk | ENSMUSP00000137377 | ENSMUSP00000053913 | Family with sequence similarity 177 member A2. | Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). | 0.504 |
Fam177a2 | Med29 | ENSMUSP00000137377 | ENSMUSP00000003536 | Family with sequence similarity 177 member A2. | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.604 |
Fam177a2 | Naa16 | ENSMUSP00000137377 | ENSMUSP00000022597 | Family with sequence similarity 177 member A2. | N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. | 0.557 |
Fam177a2 | Rnf14 | ENSMUSP00000137377 | ENSMUSP00000126205 | Family with sequence similarity 177 member A2. | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity). | 0.461 |
Fam177a2 | Steap2 | ENSMUSP00000137377 | ENSMUSP00000111086 | Family with sequence similarity 177 member A2. | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. | 0.406 |
Fam177a2 | Tcaim | ENSMUSP00000137377 | ENSMUSP00000049759 | Family with sequence similarity 177 member A2. | T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis. | 0.550 |
Lipk | Fam177a2 | ENSMUSP00000053913 | ENSMUSP00000137377 | Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). | Family with sequence similarity 177 member A2. | 0.504 |
Lipk | Naa16 | ENSMUSP00000053913 | ENSMUSP00000022597 | Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). | N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. | 0.414 |
Lipk | Tcaim | ENSMUSP00000053913 | ENSMUSP00000049759 | Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). | T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis. | 0.424 |
Med29 | Arl6ip6 | ENSMUSP00000003536 | ENSMUSP00000028336 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.644 |
Med29 | Fam177a2 | ENSMUSP00000003536 | ENSMUSP00000137377 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | Family with sequence similarity 177 member A2. | 0.604 |