node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brd1 | Fam193a | ENSMUSP00000105007 | ENSMUSP00000138082 | Bromodomain-containing 1. | Protein FAM193A; Belongs to the FAM193 family. | 0.601 |
Brd1 | Zbed4 | ENSMUSP00000105007 | ENSMUSP00000035437 | Bromodomain-containing 1. | Zinc finger BED domain-containing protein 4. | 0.490 |
Fam193a | Brd1 | ENSMUSP00000138082 | ENSMUSP00000105007 | Protein FAM193A; Belongs to the FAM193 family. | Bromodomain-containing 1. | 0.601 |
Fam193a | Gmeb1 | ENSMUSP00000138082 | ENSMUSP00000131331 | Protein FAM193A; Belongs to the FAM193 family. | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). | 0.575 |
Fam193a | Ncbp3 | ENSMUSP00000138082 | ENSMUSP00000021135 | Protein FAM193A; Belongs to the FAM193 family. | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | 0.683 |
Fam193a | Plekha7 | ENSMUSP00000138082 | ENSMUSP00000138575 | Protein FAM193A; Belongs to the FAM193 family. | Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33. | 0.476 |
Fam193a | Tbc1d10b | ENSMUSP00000138082 | ENSMUSP00000113307 | Protein FAM193A; Belongs to the FAM193 family. | TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity). | 0.529 |
Fam193a | Usp34 | ENSMUSP00000138082 | ENSMUSP00000137430 | Protein FAM193A; Belongs to the FAM193 family. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.566 |
Fam193a | Xrn1 | ENSMUSP00000138082 | ENSMUSP00000034981 | Protein FAM193A; Belongs to the FAM193 family. | 5'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation (By similarity). | 0.684 |
Fam193a | Zbed4 | ENSMUSP00000138082 | ENSMUSP00000035437 | Protein FAM193A; Belongs to the FAM193 family. | Zinc finger BED domain-containing protein 4. | 0.601 |
Fam193a | Zfp513 | ENSMUSP00000138082 | ENSMUSP00000110238 | Protein FAM193A; Belongs to the FAM193 family. | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance. | 0.515 |
Fam193a | Zgpat | ENSMUSP00000138082 | ENSMUSP00000029105 | Protein FAM193A; Belongs to the FAM193 family. | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). | 0.528 |
Gmeb1 | Fam193a | ENSMUSP00000131331 | ENSMUSP00000138082 | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). | Protein FAM193A; Belongs to the FAM193 family. | 0.575 |
Gmeb1 | Ncbp3 | ENSMUSP00000131331 | ENSMUSP00000021135 | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | 0.586 |
Ncbp3 | Fam193a | ENSMUSP00000021135 | ENSMUSP00000138082 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | Protein FAM193A; Belongs to the FAM193 family. | 0.683 |
Ncbp3 | Gmeb1 | ENSMUSP00000021135 | ENSMUSP00000131331 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). | 0.586 |
Ncbp3 | Xrn1 | ENSMUSP00000021135 | ENSMUSP00000034981 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress [...] | 5'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation (By similarity). | 0.597 |
Plekha7 | Fam193a | ENSMUSP00000138575 | ENSMUSP00000138082 | Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33. | Protein FAM193A; Belongs to the FAM193 family. | 0.476 |
Tbc1d10b | Fam193a | ENSMUSP00000113307 | ENSMUSP00000138082 | TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity). | Protein FAM193A; Belongs to the FAM193 family. | 0.529 |
Usp34 | Fam193a | ENSMUSP00000137430 | ENSMUSP00000138082 | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | Protein FAM193A; Belongs to the FAM193 family. | 0.566 |