node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Calhm3 | Efcc1 | ENSMUSP00000136302 | ENSMUSP00000138649 | Calcium homeostasis modulator protein 3; Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3- mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. | EF-hand and coiled-coil domain-containing protein 1. | 0.612 |
Calhm3 | Krt76 | ENSMUSP00000136302 | ENSMUSP00000097754 | Calcium homeostasis modulator protein 3; Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3- mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. | Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. | 0.413 |
Dqx1 | Efcc1 | ENSMUSP00000076708 | ENSMUSP00000138649 | ATP-dependent RNA helicase DQX1. | EF-hand and coiled-coil domain-containing protein 1. | 0.532 |
Efcab1 | Efcab11 | ENSMUSP00000087744 | ENSMUSP00000044808 | EF-hand calcium-binding domain-containing protein 1. | EF-hand calcium-binding domain-containing protein 11. | 0.535 |
Efcab1 | Efcc1 | ENSMUSP00000087744 | ENSMUSP00000138649 | EF-hand calcium-binding domain-containing protein 1. | EF-hand and coiled-coil domain-containing protein 1. | 0.529 |
Efcab1 | Efhc2 | ENSMUSP00000087744 | ENSMUSP00000026014 | EF-hand calcium-binding domain-containing protein 1. | EF-hand domain-containing family member C2. | 0.812 |
Efcab11 | Efcab1 | ENSMUSP00000044808 | ENSMUSP00000087744 | EF-hand calcium-binding domain-containing protein 11. | EF-hand calcium-binding domain-containing protein 1. | 0.535 |
Efcab11 | Efcc1 | ENSMUSP00000044808 | ENSMUSP00000138649 | EF-hand calcium-binding domain-containing protein 11. | EF-hand and coiled-coil domain-containing protein 1. | 0.601 |
Efcab11 | Efhc2 | ENSMUSP00000044808 | ENSMUSP00000026014 | EF-hand calcium-binding domain-containing protein 11. | EF-hand domain-containing family member C2. | 0.640 |
Efcc1 | Calhm3 | ENSMUSP00000138649 | ENSMUSP00000136302 | EF-hand and coiled-coil domain-containing protein 1. | Calcium homeostasis modulator protein 3; Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). CALHM1-CALHM3- mediated ATP released acts as a neurotransmitter to gustatory neurons in response to GPCR-mediated tastes, including sweet, bitter and umami substances. | 0.612 |
Efcc1 | Dqx1 | ENSMUSP00000138649 | ENSMUSP00000076708 | EF-hand and coiled-coil domain-containing protein 1. | ATP-dependent RNA helicase DQX1. | 0.532 |
Efcc1 | Efcab1 | ENSMUSP00000138649 | ENSMUSP00000087744 | EF-hand and coiled-coil domain-containing protein 1. | EF-hand calcium-binding domain-containing protein 1. | 0.529 |
Efcc1 | Efcab11 | ENSMUSP00000138649 | ENSMUSP00000044808 | EF-hand and coiled-coil domain-containing protein 1. | EF-hand calcium-binding domain-containing protein 11. | 0.601 |
Efcc1 | Efhc2 | ENSMUSP00000138649 | ENSMUSP00000026014 | EF-hand and coiled-coil domain-containing protein 1. | EF-hand domain-containing family member C2. | 0.562 |
Efcc1 | Hdhd5 | ENSMUSP00000138649 | ENSMUSP00000074775 | EF-hand and coiled-coil domain-containing protein 1. | Haloacid dehalogenase-like hydrolase domain-containing 5; Belongs to the HAD-like hydrolase superfamily. | 0.518 |
Efcc1 | Isy1 | ENSMUSP00000138649 | ENSMUSP00000086923 | EF-hand and coiled-coil domain-containing protein 1. | Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] | 0.525 |
Efcc1 | Krt76 | ENSMUSP00000138649 | ENSMUSP00000097754 | EF-hand and coiled-coil domain-containing protein 1. | Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. | 0.628 |
Efcc1 | Pet100 | ENSMUSP00000138649 | ENSMUSP00000137626 | EF-hand and coiled-coil domain-containing protein 1. | Protein PET100 homolog, mitochondrial; Belongs to the PET100 family. | 0.607 |
Efcc1 | Rab43 | ENSMUSP00000138649 | ENSMUSP00000077716 | EF-hand and coiled-coil domain-containing protein 1. | Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga [...] | 0.652 |
Efhc2 | Efcab1 | ENSMUSP00000026014 | ENSMUSP00000087744 | EF-hand domain-containing family member C2. | EF-hand calcium-binding domain-containing protein 1. | 0.812 |