STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prss56Serine protease 56; Serine protease required during eye development. (604 aa)    
Predicted Functional Partners:
Tmem98
Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
      
 0.854
Mfrp
Membrane frizzled-related protein; May play a role in eye development.
      
 0.753
6330403K07Rik
RIKEN cDNA 6330403K07 gene.
      
 0.604
Best1
Bestrophin-1; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity); Belongs to the bestrophin family.
      
 0.509
Lama2
Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
      
 0.502
Six6
Homeobox protein SIX6; May be involved in eye development.
   
  
 0.496
Rd3l
Retinal degeneration 3-like.
      
 0.490
Gjd2
Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily.
      
 0.486
Stox2
Storkhead-box protein 2.
      
 0.461
Adamts19
A disintegrin and metalloproteinase with thrombospondin motifs 19.
      
 0.453
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (30%) [HD]