node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdo1 | Csad | ENSRNOP00000000172 | ENSRNOP00000016205 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | 0.993 |
Cdo1 | Cth | ENSRNOP00000000172 | ENSRNOP00000058914 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.981 |
Cdo1 | Gad1 | ENSRNOP00000000172 | ENSRNOP00000072778 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.928 |
Cdo1 | Gad2 | ENSRNOP00000000172 | ENSRNOP00000024901 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.928 |
Cdo1 | Gclc | ENSRNOP00000000172 | ENSRNOP00000035540 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Glutamate--cysteine ligase catalytic subunit. | 0.845 |
Cdo1 | Gclm | ENSRNOP00000000172 | ENSRNOP00000018343 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Glutamate--cysteine ligase regulatory subunit. | 0.871 |
Cdo1 | Got1 | ENSRNOP00000000172 | ENSRNOP00000022309 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.952 |
Cdo1 | Got2 | ENSRNOP00000000172 | ENSRNOP00000015956 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.931 |
Cdo1 | Kyat1 | ENSRNOP00000000172 | ENSRNOP00000021865 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Kynurenine--oxoglutarate transaminase 1, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). | 0.901 |
Cdo1 | Suox | ENSRNOP00000000172 | ENSRNOP00000008018 | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | Sulfite oxidase, mitochondrial. | 0.921 |
Csad | Cdo1 | ENSRNOP00000016205 | ENSRNOP00000000172 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | 0.993 |
Csad | Cth | ENSRNOP00000016205 | ENSRNOP00000058914 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | 0.635 |
Csad | Gad1 | ENSRNOP00000016205 | ENSRNOP00000072778 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.903 |
Csad | Gad2 | ENSRNOP00000016205 | ENSRNOP00000024901 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Glutamate decarboxylase 2; Catalyzes the production of GABA. | 0.908 |
Csad | Got1 | ENSRNOP00000016205 | ENSRNOP00000022309 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.862 |
Csad | Got2 | ENSRNOP00000016205 | ENSRNOP00000015956 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.850 |
Csad | Suox | ENSRNOP00000016205 | ENSRNOP00000008018 | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | Sulfite oxidase, mitochondrial. | 0.492 |
Cth | Cdo1 | ENSRNOP00000058914 | ENSRNOP00000000172 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family. | 0.981 |
Cth | Csad | ENSRNOP00000058914 | ENSRNOP00000016205 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate; Belongs to the group II decarboxylase family. | 0.635 |
Cth | Gclc | ENSRNOP00000058914 | ENSRNOP00000035540 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] | Glutamate--cysteine ligase catalytic subunit. | 0.909 |