node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cerk | Cers5 | ENSRNOP00000022882 | ENSRNOP00000074498 | Ceramide kinase. | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | 0.963 |
Cerk | Cers6 | ENSRNOP00000022882 | ENSRNOP00000055558 | Ceramide kinase. | Ceramide synthase 6. | 0.962 |
Cerk | Sgms1 | ENSRNOP00000022882 | ENSRNOP00000075286 | Ceramide kinase. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...] | 0.968 |
Cerk | Sgms2 | ENSRNOP00000022882 | ENSRNOP00000015020 | Ceramide kinase. | Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] | 0.960 |
Cerk | Smpd1 | ENSRNOP00000022882 | ENSRNOP00000024224 | Ceramide kinase. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.965 |
Cerk | Smpd2 | ENSRNOP00000022882 | ENSRNOP00000000336 | Ceramide kinase. | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso- sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. | 0.970 |
Cerk | Smpd3 | ENSRNOP00000022882 | ENSRNOP00000030458 | Ceramide kinase. | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved [...] | 0.940 |
Cerk | Smpd4 | ENSRNOP00000022882 | ENSRNOP00000047410 | Ceramide kinase. | Sphingomyelin phosphodiesterase 4. | 0.929 |
Cerk | Ugcg | ENSRNOP00000022882 | ENSRNOP00000021110 | Ceramide kinase. | Ceramide glucosyltransferase; Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that m [...] | 0.980 |
Cers5 | Cerk | ENSRNOP00000074498 | ENSRNOP00000022882 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Ceramide kinase. | 0.963 |
Cers5 | Cers6 | ENSRNOP00000074498 | ENSRNOP00000055558 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Ceramide synthase 6. | 0.904 |
Cers5 | Sgms1 | ENSRNOP00000074498 | ENSRNOP00000075286 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell [...] | 0.955 |
Cers5 | Sgms2 | ENSRNOP00000074498 | ENSRNOP00000015020 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] | 0.945 |
Cers5 | Smpd1 | ENSRNOP00000074498 | ENSRNOP00000024224 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.956 |
Cers5 | Smpd2 | ENSRNOP00000074498 | ENSRNOP00000000336 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso- sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF. | 0.970 |
Cers5 | Smpd3 | ENSRNOP00000074498 | ENSRNOP00000030458 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved [...] | 0.942 |
Cers5 | Smpd4 | ENSRNOP00000074498 | ENSRNOP00000047410 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Sphingomyelin phosphodiesterase 4. | 0.924 |
Cers5 | Ugcg | ENSRNOP00000074498 | ENSRNOP00000021110 | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | Ceramide glucosyltransferase; Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that m [...] | 0.966 |
Cers6 | Cerk | ENSRNOP00000055558 | ENSRNOP00000022882 | Ceramide synthase 6. | Ceramide kinase. | 0.962 |
Cers6 | Cers5 | ENSRNOP00000055558 | ENSRNOP00000074498 | Ceramide synthase 6. | Longevity assurance homolog 5 (S. cerevisiae) (Predicted), isoform CRA_a. | 0.904 |