node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc6 | Cd74 | ENSRNOP00000033185 | ENSRNOP00000025354 | Coiled-coil domain-containing 6. | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | 0.456 |
Ccdc6 | Eml4 | ENSRNOP00000033185 | ENSRNOP00000072435 | Coiled-coil domain-containing 6. | EMAP-like 4. | 0.565 |
Ccdc6 | Gopc | ENSRNOP00000033185 | ENSRNOP00000054286 | Coiled-coil domain-containing 6. | Golgi associated PDZ and coiled-coil motif containing (Predicted). | 0.572 |
Ccdc6 | Kif5b | ENSRNOP00000033185 | ENSRNOP00000023860 | Coiled-coil domain-containing 6. | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. | 0.724 |
Ccdc6 | Lrig3 | ENSRNOP00000033185 | ENSRNOP00000030604 | Coiled-coil domain-containing 6. | Similar to Leucine-rich and immunoglobulin-like domains 3 (Predicted). | 0.703 |
Ccdc6 | Ros1 | ENSRNOP00000033185 | ENSRNOP00000068996 | Coiled-coil domain-containing 6. | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.688 |
Ccdc6 | Slc34a2 | ENSRNOP00000033185 | ENSRNOP00000050889 | Coiled-coil domain-containing 6. | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. | 0.692 |
Cd74 | Ccdc6 | ENSRNOP00000025354 | ENSRNOP00000033185 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Coiled-coil domain-containing 6. | 0.456 |
Cd74 | Eml4 | ENSRNOP00000025354 | ENSRNOP00000072435 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | EMAP-like 4. | 0.464 |
Cd74 | Lrig3 | ENSRNOP00000025354 | ENSRNOP00000030604 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Similar to Leucine-rich and immunoglobulin-like domains 3 (Predicted). | 0.556 |
Cd74 | Ros1 | ENSRNOP00000025354 | ENSRNOP00000068996 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.702 |
Cd74 | Slc34a2 | ENSRNOP00000025354 | ENSRNOP00000050889 | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. | 0.640 |
Eml4 | Ccdc6 | ENSRNOP00000072435 | ENSRNOP00000033185 | EMAP-like 4. | Coiled-coil domain-containing 6. | 0.565 |
Eml4 | Cd74 | ENSRNOP00000072435 | ENSRNOP00000025354 | EMAP-like 4. | H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. | 0.464 |
Eml4 | Kif5b | ENSRNOP00000072435 | ENSRNOP00000023860 | EMAP-like 4. | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. | 0.709 |
Eml4 | Kras | ENSRNOP00000072435 | ENSRNOP00000012588 | EMAP-like 4. | GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304- dependent manner (By similarity). | 0.720 |
Eml4 | Nras | ENSRNOP00000072435 | ENSRNOP00000036381 | EMAP-like 4. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.486 |
Eml4 | Pik3ca | ENSRNOP00000072435 | ENSRNOP00000072496 | EMAP-like 4. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology (By similarity). Participates in cel [...] | 0.541 |
Eml4 | Ros1 | ENSRNOP00000072435 | ENSRNOP00000068996 | EMAP-like 4. | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] | 0.878 |
Eml4 | Slc34a2 | ENSRNOP00000072435 | ENSRNOP00000050889 | EMAP-like 4. | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. | 0.544 |