STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Egfl8Epidermal growth factor-like protein 8. (285 aa)    
Predicted Functional Partners:
Ppt2
Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity).
 
 
 
 0.621
Dlk2
Protein delta homolog 2; Regulates adipogenesis.
      
 0.570
Prrt1
Proline-rich transmembrane protein 1.
   
 
 0.557
Dip2c
Disco-interacting protein 2 homolog C.
    
 
 0.538
Dnaaf5
Dynein, axonemal, assembly factor 5.
    
 
 0.535
Zbtb22
Zinc finger and BTB domain-containing 22.
    
 
 0.529
Megf9
EGF-like-domain, multiple 5 (Predicted).
    
 
 0.505
Fam172a
Similar to Sperm 1 POU-domain transcription factor (SPRM-1) (Predicted).
      
 0.503
Plekhg6
Pleckstrin homology and RhoGEF domain-containing G6.
      
 0.490
Gpr37l1
G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...]
   
  
 0.482
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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