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Nudt3 protein (Rattus norvegicus) - STRING interaction network
"Nudt3" - Diphosphoinositol polyphosphate phosphohydrolase 1 in Rattus norvegicus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Nudt3Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to [...] (168 aa)    
Predicted Functional Partners:
Nudt12
Nudix (nucleoside diphosphate linked moiety X)-type motif 12 (462 aa)
   
   
  0.750
Otud4
OTU deubiquitinase 4 (1105 aa)
     
   
  0.733
Nudt5
ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP- glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place [...] (219 aa)
     
 
  0.726
Nudt13
Nudix hydrolase 13; Nudix (nucleoside diphosphate linked moiety X)-type motif 13 (352 aa)
   
   
  0.717
Slc35f6
Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity) (372 aa)
         
  0.710
Nudt2
Bis(5’-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis (By similarity) (147 aa)
           
  0.700
Rhbdf2
Inactive rhomboid protein; Rhomboid 5 homolog 2 (Drosophila) (595 aa)
   
   
  0.683
Nudt7
Nudix (nucleoside diphosphate linked moiety X)-type motif 7 (236 aa)
     
   
  0.666
Etf1
Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity) (437 aa)
   
 
  0.665
Rps5
Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family (204 aa)
   
      0.665
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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