node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lats1 | Tead2 | ENSRNOP00000020098 | ENSRNOP00000028086 | Large tumor suppressor kinase 1. | TEA domain family member 2 (Mapped), isoform CRA_b. | 0.677 |
Lats1 | Tead3 | ENSRNOP00000020098 | ENSRNOP00000000607 | Large tumor suppressor kinase 1. | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | 0.668 |
Lats1 | Tead4 | ENSRNOP00000020098 | ENSRNOP00000047651 | Large tumor suppressor kinase 1. | TEA domain transcription factor 4. | 0.762 |
Lats1 | Vgll4 | ENSRNOP00000020098 | ENSRNOP00000010338 | Large tumor suppressor kinase 1. | Vestigial like 4 (Drosophila), isoform CRA_b. | 0.651 |
Lats1 | Wwtr1 | ENSRNOP00000020098 | ENSRNOP00000022507 | Large tumor suppressor kinase 1. | Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_b. | 0.993 |
Lats1 | Yap1 | ENSRNOP00000020098 | ENSRNOP00000008074 | Large tumor suppressor kinase 1. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.996 |
Lef1 | Tcf7 | ENSRNOP00000013694 | ENSRNOP00000008022 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | Transcription factor 7. | 0.855 |
Lef1 | Tcf7l1 | ENSRNOP00000013694 | ENSRNOP00000020005 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | Transcription factor 7-like 1. | 0.726 |
Lef1 | Tcf7l2-2 | ENSRNOP00000013694 | ENSRNOP00000050120 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | CTNNB1_binding domain-containing protein. | 0.782 |
Lef1 | Tead2 | ENSRNOP00000013694 | ENSRNOP00000028086 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | TEA domain family member 2 (Mapped), isoform CRA_b. | 0.816 |
Lef1 | Tead3 | ENSRNOP00000013694 | ENSRNOP00000000607 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | 0.804 |
Lef1 | Tead4 | ENSRNOP00000013694 | ENSRNOP00000047651 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | TEA domain transcription factor 4. | 0.829 |
Lef1 | Yap1 | ENSRNOP00000013694 | ENSRNOP00000008074 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.871 |
Tcf7 | Lef1 | ENSRNOP00000008022 | ENSRNOP00000013694 | Transcription factor 7. | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). | 0.855 |
Tcf7 | Tcf7l1 | ENSRNOP00000008022 | ENSRNOP00000020005 | Transcription factor 7. | Transcription factor 7-like 1. | 0.938 |
Tcf7 | Tcf7l2-2 | ENSRNOP00000008022 | ENSRNOP00000050120 | Transcription factor 7. | CTNNB1_binding domain-containing protein. | 0.915 |
Tcf7 | Tead2 | ENSRNOP00000008022 | ENSRNOP00000028086 | Transcription factor 7. | TEA domain family member 2 (Mapped), isoform CRA_b. | 0.804 |
Tcf7 | Tead3 | ENSRNOP00000008022 | ENSRNOP00000000607 | Transcription factor 7. | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. | 0.805 |
Tcf7 | Tead4 | ENSRNOP00000008022 | ENSRNOP00000047651 | Transcription factor 7. | TEA domain transcription factor 4. | 0.804 |
Tcf7 | Yap1 | ENSRNOP00000008022 | ENSRNOP00000008074 | Transcription factor 7. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.839 |