node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfsd1 | Slc29a3 | ENSRNOP00000018489 | ENSRNOP00000000689 | Major facilitator superfamily domain-containing 1. | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.555 |
Mfsd10 | Mfsd9 | ENSRNOP00000017386 | ENSRNOP00000032132 | Major facilitator superfamily domain-containing 10. | Major facilitator superfamily domain-containing 9. | 0.679 |
Mfsd10 | Slc29a1 | ENSRNOP00000017386 | ENSRNOP00000026831 | Major facilitator superfamily domain-containing 10. | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). | 0.474 |
Mfsd10 | Slc29a2 | ENSRNOP00000017386 | ENSRNOP00000027178 | Major facilitator superfamily domain-containing 10. | Equilibrative nucleoside transporter 2; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity). | 0.464 |
Mfsd10 | Slc29a3 | ENSRNOP00000017386 | ENSRNOP00000000689 | Major facilitator superfamily domain-containing 10. | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.605 |
Mfsd10 | Slc46a2 | ENSRNOP00000017386 | ENSRNOP00000023588 | Major facilitator superfamily domain-containing 10. | Thymic stromal cotransporter (Predicted). | 0.711 |
Mfsd9 | Mfsd10 | ENSRNOP00000032132 | ENSRNOP00000017386 | Major facilitator superfamily domain-containing 9. | Major facilitator superfamily domain-containing 10. | 0.679 |
Mfsd9 | Slc29a1 | ENSRNOP00000032132 | ENSRNOP00000026831 | Major facilitator superfamily domain-containing 9. | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). | 0.492 |
Mfsd9 | Slc29a2 | ENSRNOP00000032132 | ENSRNOP00000027178 | Major facilitator superfamily domain-containing 9. | Equilibrative nucleoside transporter 2; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity). | 0.474 |
Mfsd9 | Slc29a3 | ENSRNOP00000032132 | ENSRNOP00000000689 | Major facilitator superfamily domain-containing 9. | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.637 |
Mfsd9 | Slc46a2 | ENSRNOP00000032132 | ENSRNOP00000023588 | Major facilitator superfamily domain-containing 9. | Thymic stromal cotransporter (Predicted). | 0.701 |
Sgpl1 | Slc29a3 | ENSRNOP00000070983 | ENSRNOP00000000689 | Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...] | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.572 |
Slc28a1 | Slc29a1 | ENSRNOP00000070095 | ENSRNOP00000026831 | Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'- dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). | 0.883 |
Slc28a1 | Slc29a2 | ENSRNOP00000070095 | ENSRNOP00000027178 | Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'- dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). | Equilibrative nucleoside transporter 2; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity). | 0.907 |
Slc28a1 | Slc29a3 | ENSRNOP00000070095 | ENSRNOP00000000689 | Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). Transports uridine, cytidine, thymidine, and nucleoside-derived drugs. Transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'- dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.815 |
Slc28a2 | Slc29a1 | ENSRNOP00000024658 | ENSRNOP00000026831 | Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). | 0.887 |
Slc28a2 | Slc29a2 | ENSRNOP00000024658 | ENSRNOP00000027178 | Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. | Equilibrative nucleoside transporter 2; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity). | 0.907 |
Slc28a2 | Slc29a3 | ENSRNOP00000024658 | ENSRNOP00000000689 | Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity). | 0.811 |
Slc28a3 | Slc29a1 | ENSRNOP00000025745 | ENSRNOP00000026831 | Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'- azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity). | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs). | 0.854 |
Slc28a3 | Slc29a2 | ENSRNOP00000025745 | ENSRNOP00000027178 | Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'- azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity). | Equilibrative nucleoside transporter 2; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is insensitive (EI) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. Specific for nucleosides, but may also transport hypoxanthine. May also play a role in the efflux of inosine and hypoxanthine from muscle cells during the net degradation of purine nucleotides that occurs during strenuous exercise and/or in the reuptake of these purines during the recovery process (By similarity). | 0.866 |